ZNF730: every input to the diffuseness score
Protein identity: ZNF730 / ENSG00000183850. These are RNA summaries, not protein measurements or a probability of toxicity. The HPA adult/placental identity cutoff is 10%; ZNF730 remains Unsafe on independent normal-expression evidence.
For every row: similarity = N / (N + R), then contribution in percentage points = 100 × weight × similarity. Sum the last column to obtain the score. R is the source's highest Reproductive value, testis in both tables. Calculations use unrounded values; displayed values are rounded.
| Source | Normal contexts | Anatomy units | Reference | Unit | Full-panel score (%) | Same 20 anatomy units (%) |
|---|---|---|---|---|---|---|
| HPA | 38 | 29 | 4.9 | nTPM | 9.532 | 6.363 |
| GTEx | 43 | 23 | 4.914 | TPM | 1.646 | 1.708 |
The panels differ. HPA includes tonsil, lymph node, bone marrow, retina and other tissues absent from this GTEx bulk panel. GTEx includes blood, arteries and peripheral nerve absent from HPA's consensus panel. Restricting both summaries to the same 20 anatomy units gives 6.36% HPA versus 1.71% GTEx. This is a sensitivity analysis, not a newly calibrated admission rule; corresponding organs can still have different subdivisions and assay summaries.
Thus the 9.53% versus 1.65% difference reflects both panel composition and source measurements. It is not a difference measured in an identical tissue panel. The Reproductive references happen to be very similar; the normal values are not.
HPA v23 consensus
HPA v23 downloadable data · ZNF730 tissue page · Full-precision calculation CSV.
29 anatomy units each receive weight 1/29. Eight brain compartments share that weight (1/232 each); colon/rectum and small intestine/duodenum share their respective organ weights (1/58 each). Other rows have weight 1/29.
Thymus is Permissive: its 2.5 nTPM remains in the source profile, but it is excluded from both the comparator and the Reproductive reference. The denominator is 29 anatomy units, not 30 with a zero substituted for thymus.
Reproductive reference candidates
| Tissue | nTPM |
|---|---|
| testis | 4.9 |
| ovary | 2.1 |
| placenta | 1.8 |
| prostate | 1.6 |
| epididymis | 1.3 |
| endometrium | 1.2 |
| breast | 1 |
| fallopian tube | 0.9 |
| cervix | 0.5 |
| seminal vesicle | 0.4 |
| vagina | 0.2 |
Normal-tissue terms
| compartment | RNA | Weight | Similarity (%) | Contribution (pp) |
|---|---|---|---|---|
| amygdala | 0.3 | 0.00431 | 5.769 | 0.02487 |
| basal ganglia | 0.2 | 0.00431 | 3.922 | 0.0169 |
| cerebellum | 0.2 | 0.00431 | 3.922 | 0.0169 |
| cerebral cortex | 1.7 | 0.00431 | 25.76 | 0.111 |
| choroid plexus | 0.3 | 0.00431 | 5.769 | 0.02487 |
| hippocampal formation | 0.2 | 0.00431 | 3.922 | 0.0169 |
| hypothalamus | 0.5 | 0.00431 | 9.259 | 0.03991 |
| midbrain | 0.3 | 0.00431 | 5.769 | 0.02487 |
| colon | 0.4 | 0.01724 | 7.547 | 0.1301 |
| rectum | 0.7 | 0.01724 | 12.5 | 0.2155 |
| small intestine | 0 | 0.01724 | 0 | 0 |
| duodenum | 0.1 | 0.01724 | 2 | 0.03448 |
| adipose tissue | 0.2 | 0.03448 | 3.922 | 0.1352 |
| adrenal gland | 0.2 | 0.03448 | 3.922 | 0.1352 |
| appendix | 0.3 | 0.03448 | 5.769 | 0.1989 |
| bone marrow | 1.6 | 0.03448 | 24.62 | 0.8488 |
| esophagus | 0.5 | 0.03448 | 9.259 | 0.3193 |
| gallbladder | 0.8 | 0.03448 | 14.04 | 0.484 |
| heart muscle | 0.4 | 0.03448 | 7.547 | 0.2602 |
| kidney | 0.2 | 0.03448 | 3.922 | 0.1352 |
| liver | 0.1 | 0.03448 | 2 | 0.06897 |
| lung | 0.6 | 0.03448 | 10.91 | 0.3762 |
| lymph node | 1.8 | 0.03448 | 26.87 | 0.9264 |
| pancreas | 0.3 | 0.03448 | 5.769 | 0.1989 |
| parathyroid gland | 0.7 | 0.03448 | 12.5 | 0.431 |
| pituitary gland | 0.1 | 0.03448 | 2 | 0.06897 |
| retina | 0.9 | 0.03448 | 15.52 | 0.5351 |
| salivary gland | 0.2 | 0.03448 | 3.922 | 0.1352 |
| skeletal muscle | 0.3 | 0.03448 | 5.769 | 0.1989 |
| skin | 0.4 | 0.03448 | 7.547 | 0.2602 |
| smooth muscle | 1 | 0.03448 | 16.95 | 0.5845 |
| spinal cord | 0.3 | 0.03448 | 5.769 | 0.1989 |
| spleen | 0.4 | 0.03448 | 7.547 | 0.2602 |
| stomach | 0.2 | 0.03448 | 3.922 | 0.1352 |
| thyroid gland | 1 | 0.03448 | 16.95 | 0.5845 |
| tongue | 0.2 | 0.03448 | 3.922 | 0.1352 |
| tonsil | 2 | 0.03448 | 28.99 | 0.9995 |
| urinary bladder | 0.4 | 0.03448 | 7.547 | 0.2602 |
Sum: 9.53156210%. Excluding thymus reduces the prior 10.33996949% score. Tonsil, lymph node and bone marrow still count. They are absent from this direct GTEx bulk panel. Disposable tissues remain in the comparison.
Direct GTEx v11 donor medians
GTEx v11 data and release information · Full-precision calculation CSV.
23 anatomy units each receive weight 1/23, divided equally among that organ's native subdivisions. The 12 brain regions share 1/23; spinal cord is a separate unit. These are donor medians, not the highest individual-donor measurements.
Reproductive reference candidates
| Tissue | TPM |
|---|---|
| Testis | 4.914 |
| Ovary | 0.6778 |
| Cervix_Endocervix | 0.3314 |
| Uterus | 0.3243 |
| Fallopian_Tube | 0.3163 |
| Prostate | 0.3045 |
| Cervix_Ectocervix | 0.242 |
| Vagina | 0.227 |
| Breast_Mammary_Tissue | 0.156 |
Normal-tissue terms
| compartment | RNA | Weight | Similarity (%) | Contribution (pp) |
|---|---|---|---|---|
| Adipose_Subcutaneous | 0.07754 | 0.02174 | 1.553 | 0.03377 |
| Adipose_Visceral_Omentum | 0.08374 | 0.02174 | 1.676 | 0.03643 |
| Adrenal_Gland | 0.03511 | 0.04348 | 0.7093 | 0.03084 |
| Artery_Aorta | 0.1283 | 0.01449 | 2.544 | 0.03687 |
| Artery_Coronary | 0.1081 | 0.01449 | 2.152 | 0.03119 |
| Artery_Tibial | 0.03988 | 0.01449 | 0.805 | 0.01167 |
| Bladder | 0.07135 | 0.04348 | 1.431 | 0.06222 |
| Brain_Amygdala | 0.1459 | 0.003623 | 2.884 | 0.01045 |
| Brain_Anterior_cingulate_cortex_BA24 | 0.1397 | 0.003623 | 2.764 | 0.01002 |
| Brain_Caudate_basal_ganglia | 0.1375 | 0.003623 | 2.723 | 0.009864 |
| Brain_Cerebellar_Hemisphere | 0.1924 | 0.003623 | 3.767 | 0.01365 |
| Brain_Cerebellum | 0.2318 | 0.003623 | 4.505 | 0.01632 |
| Brain_Cortex | 0.1102 | 0.003623 | 2.193 | 0.007945 |
| Brain_Frontal_Cortex_BA9 | 0.119 | 0.003623 | 2.364 | 0.008564 |
| Brain_Hippocampus | 0.1058 | 0.003623 | 2.107 | 0.007636 |
| Brain_Hypothalamus | 0.3019 | 0.003623 | 5.789 | 0.02097 |
| Brain_Nucleus_accumbens_basal_ganglia | 0.1333 | 0.003623 | 2.642 | 0.009572 |
| Brain_Putamen_basal_ganglia | 0.08865 | 0.003623 | 1.772 | 0.00642 |
| Brain_Spinal_cord_cervical_c-1 | 0.2173 | 0.04348 | 4.235 | 0.1841 |
| Brain_Substantia_nigra | 0.1481 | 0.003623 | 2.925 | 0.0106 |
| Colon_Sigmoid | 0.07418 | 0.02174 | 1.487 | 0.03233 |
| Colon_Transverse | 0.1014 | 0.02174 | 2.022 | 0.04396 |
| Esophagus_Gastroesophageal_Junction | 0.07314 | 0.01449 | 1.466 | 0.02125 |
| Esophagus_Mucosa | 0.1336 | 0.01449 | 2.647 | 0.03836 |
| Esophagus_Muscularis | 0.05793 | 0.01449 | 1.165 | 0.01689 |
| Heart_Atrial_Appendage | 0.06725 | 0.02174 | 1.35 | 0.02935 |
| Heart_Left_Ventricle | 0.01575 | 0.02174 | 0.3195 | 0.006946 |
| Kidney_Cortex | 0.04949 | 0.02174 | 0.9971 | 0.02168 |
| Kidney_Medulla | 0.1233 | 0.02174 | 2.447 | 0.0532 |
| Liver | 0 | 0.04348 | 0 | 0 |
| Lung | 0.1825 | 0.04348 | 3.58 | 0.1557 |
| Minor_Salivary_Gland | 0.05438 | 0.04348 | 1.094 | 0.04758 |
| Muscle_Skeletal | 0 | 0.04348 | 0 | 0 |
| Nerve_Tibial | 0.09291 | 0.04348 | 1.856 | 0.08068 |
| Pancreas | 0.02166 | 0.04348 | 0.4388 | 0.01908 |
| Pituitary | 0.1691 | 0.04348 | 3.328 | 0.1447 |
| Skin_Not_Sun_Exposed_Suprapubic | 0.06747 | 0.02174 | 1.354 | 0.02944 |
| Skin_Sun_Exposed_Lower_leg | 0.05673 | 0.02174 | 1.141 | 0.02481 |
| Small_Intestine_Terminal_Ileum | 0.07408 | 0.04348 | 1.485 | 0.06457 |
| Spleen | 0.09589 | 0.04348 | 1.914 | 0.08322 |
| Stomach | 0.03667 | 0.04348 | 0.7407 | 0.03221 |
| Thyroid | 0.1647 | 0.04348 | 3.243 | 0.141 |
| Whole_Blood | 0 | 0.04348 | 0 | 0 |
Sum: 1.64599344%. A zero here is a measured donor median; it does not mean every donor or cell is negative. HPA also incorporates GTEx evidence, so the two sources are not independent biological replication.