Completed CTA adjudications — 25 October 2026

All 178 antibody cases remaining in the local 391-gene draft have a completed decision: 177 Neither and 1 Unsafe. No member of this discrepancy queue remains CTA. The released list has 213 CTA genes.

Current rules and funnel · All case records · Raw positive observations · Reviewed findings

Decision boundary

• Accepted endogenous protein in non-permitted normal cells excludes unrestricted gene-level use: Unsafe.
• A material raw normal stain whose molecular specificity is unresolved gives Neither. Low intensity is not, by itself, proof of nonspecific staining. A generic off-target annotation does not identify which specimens are false positives.
• Curated negative IHC and passing RNA remain useful evidence, but do not silently erase a conflicting raw stain. Enhanced profile reliability does not validate every individual primary stain.
• A clinical product recognizes a particular peptide/HLA/receptor combination. Product-specific efficacy or tolerability does not clear every protein or sequence encoded by its target gene.

These are conservative research classifications. Neither is not proven toxicity; Unsafe is not a claim that an existing therapy caused injury. Future changes require source-specific evidence revisions, not an allowlist of familiar genes.

What was actually reviewed

The 178-case review covers the pinned mapped positive primary-antibody rows, their named normal cells, intensity, primary reagents, HPA profile notes and staining summaries, with the RNA context preserved. This is a review of annotations and reagent evidence, not an independent histopathology reread of every image or new experimental validation. All 178 decisions are complete; molecular specificity remains unresolved in the raw-antibody findings. PRAME has additional accepted independent normal-protein evidence.

The eight initial cases were rechecked against their primary studies at the access depth recorded in the findings table. Full original methods were available for FTMT, YBX2, ACTRT1 and PLCZ1; other records explicitly retain abstract/excerpt and reagent-access limitations. A search result is not a full-paper adjudication. The broader 2,540-gene literature review and a continuous breadth metric remain open work.

Eight initial cases and the important clinical targets

Gene	Decision	Adjudication and limits
FTMT	Unsafe	Normal human nigral neurons with antibody specificity controls; small postmortem series. Study
ABCC11	Unsafe	Reported normal neural protein with multimodal support. Full reagent methods remain an access limitation. Study
YBX2	Unsafe	Vascular smooth-muscle/adrenal protein; not evidence of cardiomyocyte expression. Polyclonal and specimen limitations remain. Study
CCDC158	Unsafe	Reported normal renal tubular protein/function. Renal versus testicular isoforms remain unresolved; no isoform-specific clearance is claimed. Study
ACTRT1	Unsafe	Endogenous protein in differentiating normal human keratinocytes. Cultured-cell state is explicit; an RPE cell line is not normal retinal tissue evidence. Study
MAGEC2	Neither	Purkinje staining with TC-1 requires gene/family specificity resolution. Study
LGALS13	Neither	Historical extra-placental protein reactivity versus placental RNA restriction; galectin identity and anatomy are unresolved. Early study, placental study
PLCZ1	Neither	Assay correction: NYD-SP27 was measured by RT-PCR; the paper's pancreatic immunostaining measured CFTR. Reject the old PLCZ1 protein interpretation. Qualitative pancreatic RNA and isoform identity still require quantitative reconciliation. Original paper
PRAME	Unsafe	Independent monoclonal work reports low normal adrenal-cortex protein. A later negative panel using other reagents does not negate it. The initial positive study was reviewed at abstract level; clinical injury is not established. Positive study, negative panel
MAGEA4	Neither	HPA normal neuronal/epidermal stains remain unresolved. An independent OTI1F9 assay has reassuring normal-panel data but does not directly resolve the older HPA reagents. Tumor diagnostic assay performance is not whole-gene safety. Validation

Preserved therapeutic evidence: PRAME/IMA203 and MAGE-A4/afami-cel remain product-specific clinical evidence. Neither publication is discarded, and neither supplies an unrestricted gene-level rescue. CTAG1A/B and XAGE1A/B remain CTA. CTAG2 remains Neither/Variable, with the donor evidence preserved.

Every antibody case

Each heading is searchable by gene. The CSV carries exact IDs, source-native RNA maxima, reagent summaries and all contexts. “Evidence resolved = false” is a completed hold decision, not an unfinished review.

ACR — Neither

ENSG00000100312 · 5 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA048687.

Contexts: Bronchus / Respiratory epithelial cells; Colon / Glandular cells; Kidney / Cells in tubules; Nasopharynx / Respiratory epithelial cells; Rectum / Glandular cells.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000100312.

ACSBG2 — Neither

ENSG00000130377 · 20 positive raw rows; 11 Medium/High; 6 Vital Medium/High. Reagents: HPA043421; HPA051013.

Contexts: Bronchus / Respiratory epithelial cells; Colon / Glandular cells; Duodenum / Glandular cells; Heart muscle / Cardiomyocytes; Kidney / Cells in glomeruli; Kidney / Cells in tubules; Nasopharynx / Respiratory epithelial cells; Parathyroid gland / Glandular cells; Rectum / Glandular cells; Salivary gland / Glandular cells; Skeletal muscle / Myocytes; Small intestine / Glandular cells; Smooth muscle / Smooth muscle cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells; Thyroid gland / Glandular cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 11 Medium/High normal annotations (6 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000130377.

ACTL7B — Neither

ENSG00000148156 · 4 positive raw rows; 1 Medium/High; 1 Vital Medium/High. Reagents: HPA021803; HPA024664.

Contexts: Bronchus / Respiratory epithelial cells; Cerebral cortex / Neuronal cells; Skin 1 / Fibroblasts; Smooth muscle / Smooth muscle cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 1 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000148156.

ADAM2 — Neither

ENSG00000104755 · 28 positive raw rows; 16 Medium/High; 11 Vital Medium/High. Reagents: CAB022390; HPA024621; HPA026581.

Contexts: Adrenal gland / Glandular cells; Caudate / Neuronal cells; Cerebral cortex / Glial cells; Cerebral cortex / Neuronal cells; Colon / Glandular cells; Duodenum / Glandular cells; Esophagus / Squamous epithelial cells; Heart muscle / Cardiomyocytes; Hippocampus / Neuronal cells; Lung / Macrophages; Oral mucosa / Squamous epithelial cells; Pancreas / Exocrine glandular cells; Pancreas / Pancreatic endocrine cells; Parathyroid gland / Glandular cells; Rectum / Glandular cells; Salivary gland / Glandular cells; Skeletal muscle / Myocytes; Small intestine / Glandular cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells; Thyroid gland / Glandular cells.

Decision: 16 Medium/High normal annotations (11 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000104755.

AKAP4 — Neither

ENSG00000147081 · 14 positive raw rows; 3 Medium/High; 2 Vital Medium/High. Reagents: HPA005949; HPA020046.

Contexts: Bronchus / Respiratory epithelial cells; Caudate / Neuronal cells; Cerebellum / Cells in molecular layer; Cerebellum / Purkinje cells; Cerebral cortex / Neuronal cells; Hippocampus / Glial cells; Hippocampus / Neuronal cells; Lung / Macrophages; Nasopharynx / Respiratory epithelial cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells.

Decision: 3 Medium/High normal annotations (2 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000147081.

ASZ1 — Neither

ENSG00000154438 · 8 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA020558.

Contexts: Adrenal gland / Glandular cells; Caudate / Neuronal cells; Cerebral cortex / Neuronal cells; Colon / Glandular cells; Duodenum / Glandular cells; Kidney / Cells in tubules; Rectum / Glandular cells; Salivary gland / Glandular cells.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000154438.

BOLL — Neither

ENSG00000152430 · 12 positive raw rows; 1 Medium/High; 1 Vital Medium/High. Reagents: HPA018678; HPA048813.

Contexts: Bone marrow / Hematopoietic cells; Bronchus / Respiratory epithelial cells; Caudate / Neuronal cells; Cerebellum / Purkinje cells; Cerebral cortex / Endothelial cells; Cerebral cortex / Neuronal cells; Kidney / Cells in tubules; Lung / Macrophages; Lymph node / Non-germinal center cells; Spleen / Cells in red pulp; Thyroid gland / Glandular cells.

Decision: 1 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000152430.

C10orf53 — Neither

ENSG00000178645 · 2 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA037951.

Contexts: Kidney / Cells in tubules; Salivary gland / Glandular cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000178645.

C10orf62 — Neither

ENSG00000203942 · 6 positive raw rows; 1 Medium/High; 1 Vital Medium/High. Reagents: HPA072947.

Contexts: Caudate / Neuronal cells; Cerebellum / Purkinje cells; Cerebral cortex / Neuronal cells; Cerebral cortex / Neuropil; Hippocampus / Neuronal cells; Nasopharynx / Respiratory epithelial cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 1 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000203942.

C11orf42 — Neither

ENSG00000180878 · 2 positive raw rows; 1 Medium/High; 1 Vital Medium/High. Reagents: HPA063404.

Contexts: Adrenal gland / Glandular cells; Smooth muscle / Smooth muscle cells.

Decision: 1 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000180878.

C20orf144 — Neither

ENSG00000149609 · 1 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA019029.

Contexts: Salivary gland / Glandular cells.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000149609.

CABS1 — Neither

ENSG00000145309 · 3 positive raw rows; 1 Medium/High; 0 Vital Medium/High. Reagents: HPA055352.

Contexts: Duodenum / Glandular cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells.

Decision: 1 Medium/High normal annotations (0 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000145309.

CALR3 — Neither

ENSG00000269058 · 4 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: CAB025749.

Contexts: Caudate / Neuronal cells; Cerebral cortex / Neuronal cells; Lymph node / Non-germinal center cells; Spleen / Cells in red pulp.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000269058.

CAPZA3 — Neither

ENSG00000177938 · 4 positive raw rows; 2 Medium/High; 2 Vital Medium/High. Reagents: HPA038688.

Contexts: Colon / Glandular cells; Duodenum / Glandular cells; Rectum / Glandular cells; Small intestine / Glandular cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 2 Medium/High normal annotations (2 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000177938.

CATSPER4 — Neither

ENSG00000188782 · 2 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA045257.

Contexts: Bronchus / Respiratory epithelial cells; Small intestine / Glandular cells.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000188782.

CBY2 — Neither

ENSG00000174015 · 2 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA039359.

Contexts: Skin 1 / Keratinocytes; Stomach 2 / Glandular cells.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000174015.

CETN1 — Neither

ENSG00000177143 · 41 positive raw rows; 23 Medium/High; 13 Vital Medium/High. Reagents: CAB037244; HPA028956; HPA069157.

Contexts: Adrenal gland / Glandular cells; Bone marrow / Hematopoietic cells; Bronchus / Respiratory epithelial cells; Caudate / Glial cells; Caudate / Neuronal cells; Cerebellum / Cells in granular layer; Cerebellum / Cells in molecular layer; Cerebellum / Purkinje cells; Cerebral cortex / Glial cells; Cerebral cortex / Neuronal cells; Cerebral cortex / Neuropil; Colon / Endothelial cells; Duodenum / Glandular cells; Esophagus / Squamous epithelial cells; Heart muscle / Cardiomyocytes; Hippocampus / Glial cells; Hippocampus / Neuronal cells; Kidney / Cells in tubules; Liver / Cholangiocytes; Lung / Alveolar cells; Lung / Macrophages; Nasopharynx / Respiratory epithelial cells; Oral mucosa / Squamous epithelial cells; Pancreas / Exocrine glandular cells; Pancreas / Pancreatic endocrine cells; Parathyroid gland / Glandular cells; Rectum / Glandular cells; Salivary gland / Glandular cells; Skeletal muscle / Myocytes; Skin 1 / Fibroblasts; Skin 1 / Keratinocytes; Skin 1 / Langerhans; Skin 2 / Epidermal cells; Small intestine / Glandular cells; Smooth muscle / Smooth muscle cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells; Thyroid gland / Glandular cells; Urinary bladder / Urothelial cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 23 Medium/High normal annotations (13 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000177143.

CFAP97D1 — Neither

ENSG00000231256 · 17 positive raw rows; 6 Medium/High; 3 Vital Medium/High. Reagents: HPA053028.

Contexts: Bronchus / Respiratory epithelial cells; Cerebral cortex / Neuropil; Colon / Endothelial cells; Colon / Glandular cells; Colon / Peripheral nerve/ganglion; Duodenum / Glandular cells; Esophagus / Squamous epithelial cells; Heart muscle / Cardiomyocytes; Kidney / Cells in tubules; Parathyroid gland / Glandular cells; Rectum / Glandular cells; Salivary gland / Glandular cells; Skeletal muscle / Myocytes; Small intestine / Glandular cells; Smooth muscle / Smooth muscle cells; Stomach 1 / Glandular cells; Urinary bladder / Urothelial cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 6 Medium/High normal annotations (3 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000231256.

CGB3 — Neither

ENSG00000104827 · 22 positive raw rows; 14 Medium/High; 8 Vital Medium/High. Reagents: CAB010884; HPA038925.

Contexts: Adrenal gland / Glandular cells; Bronchus / Respiratory epithelial cells; Caudate / Neuronal cells; Cerebral cortex / Neuronal cells; Duodenum / Glandular cells; Heart muscle / Cardiomyocytes; Kidney / Cells in tubules; Liver / Hepatocytes; Lung / Alveolar cells; Lung / Macrophages; Nasopharynx / Respiratory epithelial cells; Pancreas / Exocrine glandular cells; Parathyroid gland / Glandular cells; Rectum / Glandular cells; Salivary gland / Glandular cells; Skin 1 / Keratinocytes; Small intestine / Glandular cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells; Thyroid gland / Glandular cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. 14 Medium/High normal annotations (8 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000104827.

CHCT1 — Neither

ENSG00000141371 · 4 positive raw rows; 2 Medium/High; 1 Vital Medium/High. Reagents: HPA044415.

Contexts: Pancreas / Exocrine glandular cells; Salivary gland / Glandular cells; Smooth muscle / Smooth muscle cells; Stomach 2 / Glandular cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 2 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000141371.

CIMAP1A — Neither

ENSG00000177947 · 15 positive raw rows; 3 Medium/High; 3 Vital Medium/High. Reagents: HPA038919; HPA039241.

Contexts: Adrenal gland / Glandular cells; Bronchus / Respiratory epithelial cells; Caudate / Glial cells; Caudate / Neuronal cells; Cerebral cortex / Glial cells; Cerebral cortex / Neuronal cells; Duodenum / Glandular cells; Esophagus / Squamous epithelial cells; Hippocampus / Glial cells; Liver / Hepatocytes; Oral mucosa / Squamous epithelial cells; Salivary gland / Glandular cells; Skin 2 / Epidermal cells; Smooth muscle / Smooth muscle cells; Stomach 2 / Glandular cells.

Decision: 3 Medium/High normal annotations (3 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000177947.

CIMIP2A — Neither

ENSG00000188163 · 1 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA023307.

Contexts: Parathyroid gland / Glandular cells.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000188163.

CIMIP4 — Neither

ENSG00000185264 · 15 positive raw rows; 4 Medium/High; 1 Vital Medium/High. Reagents: HPA005998.

Contexts: Adrenal gland / Glandular cells; Cerebellum / Purkinje cells; Colon / Glandular cells; Duodenum / Glandular cells; Heart muscle / Cardiomyocytes; Lung / Alveolar cells; Lung / Macrophages; Nasopharynx / Respiratory epithelial cells; Parathyroid gland / Glandular cells; Rectum / Glandular cells; Skin 2 / Epidermal cells; Small intestine / Glandular cells; Smooth muscle / Smooth muscle cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells.

Decision: 4 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000185264.

CT45A10 — Neither

ENSG00000269586 · 38 positive raw rows; 12 Medium/High; 10 Vital Medium/High. Reagents: HPA044735; HPA044757; HPA046872; HPA046987.

Contexts: Adrenal gland / Glandular cells; Bone marrow / Hematopoietic cells; Bronchus / Respiratory epithelial cells; Caudate / Glial cells; Caudate / Neuronal cells; Cerebral cortex / Neuronal cells; Colon / Glandular cells; Duodenum / Glandular cells; Esophagus / Squamous epithelial cells; Heart muscle / Cardiomyocytes; Hippocampus / Neuronal cells; Kidney / Cells in tubules; Lung / Macrophages; Nasopharynx / Respiratory epithelial cells; Oral mucosa / Squamous epithelial cells; Pancreas / Exocrine glandular cells; Parathyroid gland / Glandular cells; Rectum / Glandular cells; Salivary gland / Glandular cells; Skeletal muscle / Myocytes; Skin 2 / Epidermal cells; Small intestine / Glandular cells; Smooth muscle / Smooth muscle cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells; Urinary bladder / Urothelial cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 12 Medium/High normal annotations (10 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000269586.

CT45A2 — Neither

ENSG00000271449 · 38 positive raw rows; 12 Medium/High; 10 Vital Medium/High. Reagents: HPA044735; HPA044757; HPA046872; HPA046987.

Contexts: Adrenal gland / Glandular cells; Bone marrow / Hematopoietic cells; Bronchus / Respiratory epithelial cells; Caudate / Glial cells; Caudate / Neuronal cells; Cerebral cortex / Neuronal cells; Colon / Glandular cells; Duodenum / Glandular cells; Esophagus / Squamous epithelial cells; Heart muscle / Cardiomyocytes; Hippocampus / Neuronal cells; Kidney / Cells in tubules; Lung / Macrophages; Nasopharynx / Respiratory epithelial cells; Oral mucosa / Squamous epithelial cells; Pancreas / Exocrine glandular cells; Parathyroid gland / Glandular cells; Rectum / Glandular cells; Salivary gland / Glandular cells; Skeletal muscle / Myocytes; Skin 2 / Epidermal cells; Small intestine / Glandular cells; Smooth muscle / Smooth muscle cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells; Urinary bladder / Urothelial cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 12 Medium/High normal annotations (10 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000271449.

CT45A7 — Neither

ENSG00000273696 · 38 positive raw rows; 12 Medium/High; 10 Vital Medium/High. Reagents: HPA044735; HPA044757; HPA046872; HPA046987.

Contexts: Adrenal gland / Glandular cells; Bone marrow / Hematopoietic cells; Bronchus / Respiratory epithelial cells; Caudate / Glial cells; Caudate / Neuronal cells; Cerebral cortex / Neuronal cells; Colon / Glandular cells; Duodenum / Glandular cells; Esophagus / Squamous epithelial cells; Heart muscle / Cardiomyocytes; Hippocampus / Neuronal cells; Kidney / Cells in tubules; Lung / Macrophages; Nasopharynx / Respiratory epithelial cells; Oral mucosa / Squamous epithelial cells; Pancreas / Exocrine glandular cells; Parathyroid gland / Glandular cells; Rectum / Glandular cells; Salivary gland / Glandular cells; Skeletal muscle / Myocytes; Skin 2 / Epidermal cells; Small intestine / Glandular cells; Smooth muscle / Smooth muscle cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells; Urinary bladder / Urothelial cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 12 Medium/High normal annotations (10 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000273696.

CT47A1 — Neither

ENSG00000236371 · 2 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA042483.

Contexts: Bone marrow / Hematopoietic cells; Lymph node / Non-germinal center cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000236371.

CT47A10 — Neither

ENSG00000224089 · 2 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA042483.

Contexts: Bone marrow / Hematopoietic cells; Lymph node / Non-germinal center cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000224089.

CT47A11 — Neither

ENSG00000226929 · 2 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA042483.

Contexts: Bone marrow / Hematopoietic cells; Lymph node / Non-germinal center cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000226929.

CT47A12 — Neither

ENSG00000226685 · 2 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA042483.

Contexts: Bone marrow / Hematopoietic cells; Lymph node / Non-germinal center cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000226685.

CT47A2 — Neither

ENSG00000242362 · 2 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA042483.

Contexts: Bone marrow / Hematopoietic cells; Lymph node / Non-germinal center cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000242362.

CT47A3 — Neither

ENSG00000236126 · 2 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA042483.

Contexts: Bone marrow / Hematopoietic cells; Lymph node / Non-germinal center cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000236126.

CT47A4 — Neither

ENSG00000230594 · 2 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA042483.

Contexts: Bone marrow / Hematopoietic cells; Lymph node / Non-germinal center cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000230594.

CT47A5 — Neither

ENSG00000237957 · 2 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA042483.

Contexts: Bone marrow / Hematopoietic cells; Lymph node / Non-germinal center cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000237957.

CT47A6 — Neither

ENSG00000226023 · 2 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA042483.

Contexts: Bone marrow / Hematopoietic cells; Lymph node / Non-germinal center cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000226023.

CT47A7 — Neither

ENSG00000228517 · 2 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA042483.

Contexts: Bone marrow / Hematopoietic cells; Lymph node / Non-germinal center cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000228517.

CT47A8 — Neither

ENSG00000230347 · 2 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA042483.

Contexts: Bone marrow / Hematopoietic cells; Lymph node / Non-germinal center cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000230347.

CT47A9 — Neither

ENSG00000226600 · 2 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA042483.

Contexts: Bone marrow / Hematopoietic cells; Lymph node / Non-germinal center cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000226600.

CT47B1 — Neither

ENSG00000236446 · 2 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA042483.

Contexts: Bone marrow / Hematopoietic cells; Lymph node / Non-germinal center cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000236446.

CTCFL — Neither

ENSG00000124092 · 3 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA001472.

Contexts: Rectum / Glandular cells; Small intestine / Glandular cells; Stomach 2 / Glandular cells.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000124092.

CYLC1 — Neither

ENSG00000183035 · 1 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA070355.

Contexts: Parathyroid gland / Glandular cells.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000183035.

DAZ3 — Neither

ENSG00000187191 · 5 positive raw rows; 3 Medium/High; 3 Vital Medium/High. Reagents: HPA047113.

Contexts: Colon / Glandular cells; Duodenum / Glandular cells; Kidney / Cells in tubules; Rectum / Glandular cells; Small intestine / Glandular cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. 3 Medium/High normal annotations (3 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000187191.

DDI1 — Neither

ENSG00000170967 · 1 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA079511.

Contexts: Lymph node / Non-germinal center cells.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000170967.

DDX4 — Neither

ENSG00000152670 · 34 positive raw rows; 15 Medium/High; 9 Vital Medium/High. Reagents: CAB026170; HPA037763; HPA037764.

Contexts: Adrenal gland / Glandular cells; Caudate / Glial cells; Caudate / Neuronal cells; Cerebellum / Cells in molecular layer; Cerebral cortex / Glial cells; Cerebral cortex / Neuronal cells; Colon / Glandular cells; Colon / Peripheral nerve/ganglion; Duodenum / Glandular cells; Esophagus / Squamous epithelial cells; Heart muscle / Cardiomyocytes; Hippocampus / Neuronal cells; Kidney / Cells in tubules; Liver / Hepatocytes; Lung / Macrophages; Nasopharynx / Respiratory epithelial cells; Oral mucosa / Squamous epithelial cells; Pancreas / Exocrine glandular cells; Rectum / Glandular cells; Salivary gland / Glandular cells; Skeletal muscle / Myocytes; Skin 1 / Keratinocytes; Skin 1 / Langerhans; Small intestine / Glandular cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells; Thyroid gland / Glandular cells; Urinary bladder / Urothelial cells.

Decision: 15 Medium/High normal annotations (9 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000152670.

DKKL1 — Neither

ENSG00000104901 · 7 positive raw rows; 1 Medium/High; 0 Vital Medium/High. Reagents: CAB025410.

Contexts: Caudate / Neuronal cells; Kidney / Cells in glomeruli; Nasopharynx / Respiratory epithelial cells; Rectum / Glandular cells; Skeletal muscle / Myocytes; Smooth muscle / Smooth muscle cells; Urinary bladder / Urothelial cells.

Decision: 1 Medium/High normal annotations (0 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000104901.

DMRT1 — Neither

ENSG00000137090 · 6 positive raw rows; 2 Medium/High; 1 Vital Medium/High. Reagents: HPA027850.

Contexts: Adrenal gland / Glandular cells; Kidney / Cells in tubules; Liver / Hepatocytes; Lung / Macrophages; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 2 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000137090.

DMRTB1 — Neither

ENSG00000143006 · 15 positive raw rows; 4 Medium/High; 2 Vital Medium/High. Reagents: HPA036490; HPA058553.

Contexts: Adipose tissue / Adipocytes; Adrenal gland / Glandular cells; Bronchus / Respiratory epithelial cells; Cerebral cortex / Endothelial cells; Colon / Endothelial cells; Colon / Glandular cells; Colon / Peripheral nerve/ganglion; Heart muscle / Cardiomyocytes; Kidney / Cells in glomeruli; Lung / Macrophages; Nasopharynx / Respiratory epithelial cells; Skin 1 / Fibroblasts; Skin 1 / Langerhans; Skin 2 / Epidermal cells.

Decision: 4 Medium/High normal annotations (2 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000143006.

DNAJC5G — Neither

ENSG00000163793 · 8 positive raw rows; 2 Medium/High; 1 Vital Medium/High. Reagents: HPA041445.

Contexts: Bone marrow / Hematopoietic cells; Esophagus / Squamous epithelial cells; Oral mucosa / Squamous epithelial cells; Salivary gland / Glandular cells; Skin 1 / Keratinocytes; Skin 2 / Epidermal cells; Spleen / Cells in red pulp; Thyroid gland / Glandular cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 2 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000163793.

EDDM3B — Neither

ENSG00000181552 · 2 positive raw rows; 1 Medium/High; 1 Vital Medium/High. Reagents: HPA001323.

Contexts: Bronchus / Respiratory epithelial cells; Nasopharynx / Respiratory epithelial cells.

Decision: 1 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000181552.

EQTN — Neither

ENSG00000120160 · 1 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA015089.

Contexts: Adrenal gland / Glandular cells.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000120160.

EZHIP — Neither

ENSG00000187690 · 8 positive raw rows; 1 Medium/High; 1 Vital Medium/High. Reagents: HPA004003; HPA006128.

Contexts: Bronchus / Respiratory epithelial cells; Cerebral cortex / Neuronal cells; Kidney / Cells in tubules; Skin 1 / Keratinocytes; Skin 1 / Langerhans; Skin 2 / Epidermal cells.

Decision: 1 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000187690.

FAM170A — Neither

ENSG00000164334 · 16 positive raw rows; 8 Medium/High; 4 Vital Medium/High. Reagents: HPA037900; HPA037902.

Contexts: Adrenal gland / Glandular cells; Caudate / Neuronal cells; Cerebellum / Purkinje cells; Cerebral cortex / Neuronal cells; Cerebral cortex / Neuropil; Colon / Glandular cells; Esophagus / Squamous epithelial cells; Hippocampus / Neuronal cells; Kidney / Cells in tubules; Lung / Macrophages; Nasopharynx / Respiratory epithelial cells; Pancreas / Exocrine glandular cells; Salivary gland / Glandular cells; Skin 1 / Keratinocytes; Skin 2 / Epidermal cells; Stomach 2 / Glandular cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 8 Medium/High normal annotations (4 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000164334.

FAM187B — Neither

ENSG00000177558 · 1 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA079535.

Contexts: Kidney / Cells in tubules.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000177558.

FAM24A — Neither

ENSG00000203795 · 2 positive raw rows; 2 Medium/High; 1 Vital Medium/High. Reagents: HPA052490.

Contexts: Bronchus / Respiratory epithelial cells; Nasopharynx / Respiratory epithelial cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 2 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000203795.

FBXO24 — Neither

ENSG00000106336 · 4 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA050951.

Contexts: Adrenal gland / Glandular cells; Caudate / Neuronal cells; Cerebral cortex / Neuronal cells; Hippocampus / Neuronal cells.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000106336.

FKBP6 — Neither

ENSG00000077800 · 5 positive raw rows; 1 Medium/High; 1 Vital Medium/High. Reagents: HPA061109.

Contexts: Adrenal gland / Glandular cells; Bronchus / Respiratory epithelial cells; Caudate / Glial cells; Cerebellum / Cells in granular layer; Kidney / Cells in tubules.

Decision: 1 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000077800.

FMR1NB — Neither

ENSG00000176988 · 18 positive raw rows; 2 Medium/High; 1 Vital Medium/High. Reagents: CAB026403; HPA011284.

Contexts: Adrenal gland / Glandular cells; Bronchus / Respiratory epithelial cells; Caudate / Neuronal cells; Cerebral cortex / Neuronal cells; Hippocampus / Neuronal cells; Kidney / Cells in tubules; Nasopharynx / Respiratory epithelial cells; Oral mucosa / Squamous epithelial cells; Pancreas / Exocrine glandular cells; Pancreas / Pancreatic endocrine cells; Parathyroid gland / Glandular cells; Rectum / Glandular cells; Skin 1 / Keratinocytes; Smooth muscle / Smooth muscle cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells; Urinary bladder / Urothelial cells.

Decision: 2 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000176988.

FNDC8 — Neither

ENSG00000073598 · 8 positive raw rows; 5 Medium/High; 3 Vital Medium/High. Reagents: HPA026521.

Contexts: Bronchus / Respiratory epithelial cells; Colon / Glandular cells; Duodenum / Glandular cells; Kidney / Cells in tubules; Lung / Macrophages; Pancreas / Exocrine glandular cells; Rectum / Glandular cells; Small intestine / Glandular cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 5 Medium/High normal annotations (3 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000073598.

FSCB — Neither

ENSG00000189139 · 14 positive raw rows; 7 Medium/High; 5 Vital Medium/High. Reagents: HPA003546.

Contexts: Caudate / Neuronal cells; Cerebellum / Cells in molecular layer; Cerebellum / Purkinje cells; Cerebral cortex / Neuronal cells; Colon / Glandular cells; Hippocampus / Neuronal cells; Kidney / Cells in tubules; Lung / Macrophages; Oral mucosa / Squamous epithelial cells; Salivary gland / Glandular cells; Skeletal muscle / Myocytes; Small intestine / Glandular cells; Smooth muscle / Smooth muscle cells; Thyroid gland / Glandular cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 7 Medium/High normal annotations (5 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000189139.

GARIN3 — Neither

ENSG00000170613 · 7 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA039478; HPA040771.

Contexts: Colon / Endothelial cells; Colon / Glandular cells; Esophagus / Squamous epithelial cells; Rectum / Glandular cells; Small intestine / Glandular cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000170613.

GDF9 — Neither

ENSG00000164404 · 3 positive raw rows; 1 Medium/High; 1 Vital Medium/High. Reagents: HPA069146.

Contexts: Adrenal gland / Glandular cells; Heart muscle / Cardiomyocytes; Pancreas / Exocrine glandular cells.

Decision: 1 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000164404.

GLIPR1L1 — Neither

ENSG00000173401 · 3 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA042095.

Contexts: Adrenal gland / Glandular cells; Kidney / Cells in tubules; Lung / Macrophages.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000173401.

GOLGA6A — Neither

ENSG00000159289 · 15 positive raw rows; 5 Medium/High; 2 Vital Medium/High. Reagents: HPA044978; HPA050087.

Contexts: Adrenal gland / Glandular cells; Bone marrow / Hematopoietic cells; Cerebellum / Purkinje cells; Cerebral cortex / Neuronal cells; Esophagus / Squamous epithelial cells; Kidney / Cells in glomeruli; Kidney / Cells in tubules; Lung / Macrophages; Lymph node / Non-germinal center cells; Parathyroid gland / Glandular cells; Skin 1 / Keratinocytes; Skin 2 / Epidermal cells; Smooth muscle / Smooth muscle cells; Spleen / Cells in red pulp.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. 5 Medium/High normal annotations (2 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000159289.

GOLGA6C — Neither

ENSG00000167195 · 15 positive raw rows; 5 Medium/High; 2 Vital Medium/High. Reagents: HPA044978; HPA050087.

Contexts: Adrenal gland / Glandular cells; Bone marrow / Hematopoietic cells; Cerebellum / Purkinje cells; Cerebral cortex / Neuronal cells; Esophagus / Squamous epithelial cells; Kidney / Cells in glomeruli; Kidney / Cells in tubules; Lung / Macrophages; Lymph node / Non-germinal center cells; Parathyroid gland / Glandular cells; Skin 1 / Keratinocytes; Skin 2 / Epidermal cells; Smooth muscle / Smooth muscle cells; Spleen / Cells in red pulp.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. 5 Medium/High normal annotations (2 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000167195.

GOLGA6D — Neither

ENSG00000140478 · 15 positive raw rows; 5 Medium/High; 2 Vital Medium/High. Reagents: HPA044978; HPA050087.

Contexts: Adrenal gland / Glandular cells; Bone marrow / Hematopoietic cells; Cerebellum / Purkinje cells; Cerebral cortex / Neuronal cells; Esophagus / Squamous epithelial cells; Kidney / Cells in glomeruli; Kidney / Cells in tubules; Lung / Macrophages; Lymph node / Non-germinal center cells; Parathyroid gland / Glandular cells; Skin 1 / Keratinocytes; Skin 2 / Epidermal cells; Smooth muscle / Smooth muscle cells; Spleen / Cells in red pulp.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. 5 Medium/High normal annotations (2 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000140478.

H2AP — Neither

ENSG00000187516 · 10 positive raw rows; 1 Medium/High; 1 Vital Medium/High. Reagents: HPA003356.

Contexts: Bronchus / Respiratory epithelial cells; Caudate / Neuronal cells; Duodenum / Glandular cells; Esophagus / Squamous epithelial cells; Kidney / Cells in tubules; Oral mucosa / Squamous epithelial cells; Rectum / Glandular cells; Small intestine / Glandular cells; Thyroid gland / Glandular cells; Urinary bladder / Urothelial cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 1 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000187516.

HDGFL1 — Neither

ENSG00000112273 · 1 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA063707.

Contexts: Small intestine / Glandular cells.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000112273.

HHIPL2 — Neither

ENSG00000143512 · 2 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA059673.

Contexts: Cerebral cortex / Neuronal cells; Hippocampus / Neuronal cells.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000143512.

HORMAD2 — Neither

ENSG00000176635 · 1 positive raw rows; 1 Medium/High; 1 Vital Medium/High. Reagents: HPA003074.

Contexts: Cerebral cortex / Neuropil.

Decision: 1 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000176635.

HSFX2 — Neither

ENSG00000268738 · 1 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA063040.

Contexts: Stomach 2 / Glandular cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000268738.

IHO1 — Neither

ENSG00000173421 · 18 positive raw rows; 4 Medium/High; 3 Vital Medium/High. Reagents: HPA045690.

Contexts: Adrenal gland / Glandular cells; Bone marrow / Hematopoietic cells; Bronchus / Respiratory epithelial cells; Cerebral cortex / Endothelial cells; Cerebral cortex / Glial cells; Colon / Glandular cells; Duodenum / Glandular cells; Heart muscle / Cardiomyocytes; Hippocampus / Neuronal cells; Kidney / Cells in tubules; Pancreas / Exocrine glandular cells; Pancreas / Pancreatic endocrine cells; Rectum / Glandular cells; Skeletal muscle / Myocytes; Small intestine / Glandular cells; Spleen / Cells in red pulp; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 4 Medium/High normal annotations (3 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000173421.

IRGC — Neither

ENSG00000124449 · 19 positive raw rows; 8 Medium/High; 4 Vital Medium/High. Reagents: HPA046769; HPA060064.

Contexts: Adrenal gland / Glandular cells; Bronchus / Respiratory epithelial cells; Cerebellum / Purkinje cells; Colon / Endothelial cells; Colon / Glandular cells; Duodenum / Glandular cells; Heart muscle / Cardiomyocytes; Kidney / Cells in tubules; Parathyroid gland / Glandular cells; Rectum / Glandular cells; Salivary gland / Glandular cells; Small intestine / Glandular cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells; Thyroid gland / Glandular cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 8 Medium/High normal annotations (4 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000124449.

KIAA1210 — Neither

ENSG00000250423 · 20 positive raw rows; 10 Medium/High; 4 Vital Medium/High. Reagents: HPA048322.

Contexts: Caudate / Neuronal cells; Cerebellum / Cells in molecular layer; Cerebral cortex / Endothelial cells; Cerebral cortex / Neuronal cells; Colon / Glandular cells; Duodenum / Glandular cells; Liver / Hepatocytes; Lung / Alveolar cells; Lung / Macrophages; Lymph node / Non-germinal center cells; Nasopharynx / Respiratory epithelial cells; Pancreas / Exocrine glandular cells; Rectum / Glandular cells; Salivary gland / Glandular cells; Skin 1 / Fibroblasts; Skin 2 / Epidermal cells; Small intestine / Glandular cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells; Thyroid gland / Glandular cells.

Decision: 10 Medium/High normal annotations (4 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000250423.

KLF17 — Neither

ENSG00000171872 · 4 positive raw rows; 3 Medium/High; 1 Vital Medium/High. Reagents: HPA024629.

Contexts: Bone marrow / Hematopoietic cells; Bronchus / Respiratory epithelial cells; Spleen / Cells in red pulp; Spleen / Cells in white pulp.

Decision: 3 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000171872.

LDHAL6B — Neither

ENSG00000171989 · 12 positive raw rows; 5 Medium/High; 4 Vital Medium/High. Reagents: HPA053962.

Contexts: Adipose tissue / Adipocytes; Bone marrow / Hematopoietic cells; Cerebellum / Purkinje cells; Cerebral cortex / Endothelial cells; Heart muscle / Cardiomyocytes; Kidney / Cells in tubules; Nasopharynx / Respiratory epithelial cells; Parathyroid gland / Glandular cells; Rectum / Glandular cells; Salivary gland / Glandular cells; Skeletal muscle / Myocytes; Thyroid gland / Glandular cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 5 Medium/High normal annotations (4 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000171989.

LRRD1 — Neither

ENSG00000240720 · 1 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA079440.

Contexts: Stomach 1 / Glandular cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000240720.

LYZL4 — Neither

ENSG00000157093 · 18 positive raw rows; 9 Medium/High; 4 Vital Medium/High. Reagents: HPA038806.

Contexts: Adipose tissue / Adipocytes; Caudate / Glial cells; Caudate / Neuronal cells; Cerebral cortex / Neuronal cells; Colon / Glandular cells; Duodenum / Glandular cells; Heart muscle / Cardiomyocytes; Kidney / Cells in tubules; Liver / Hepatocytes; Lung / Alveolar cells; Lung / Macrophages; Pancreas / Exocrine glandular cells; Rectum / Glandular cells; Skeletal muscle / Myocytes; Skin 1 / Fibroblasts; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells; Urinary bladder / Urothelial cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 9 Medium/High normal annotations (4 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000157093.

LYZL6 — Neither

ENSG00000275722 · 14 positive raw rows; 3 Medium/High; 0 Vital Medium/High. Reagents: HPA025734; HPA053073.

Contexts: Adrenal gland / Glandular cells; Cerebellum / Purkinje cells; Cerebral cortex / Endothelial cells; Cerebral cortex / Neuronal cells; Colon / Endothelial cells; Colon / Glandular cells; Duodenum / Glandular cells; Lung / Macrophages; Rectum / Glandular cells; Skeletal muscle / Myocytes; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells; Thyroid gland / Glandular cells; Urinary bladder / Urothelial cells.

Decision: 3 Medium/High normal annotations (0 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000275722.

MAGEA1 — Neither

ENSG00000198681 · 6 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: CAB002620.

Contexts: Adipose tissue / Adipocytes; Caudate / Neuronal cells; Cerebral cortex / Neuronal cells; Hippocampus / Neuronal cells; Kidney / Cells in glomeruli; Kidney / Cells in tubules.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000198681.

MAGEA10 — Neither

ENSG00000124260 · 19 positive raw rows; 8 Medium/High; 4 Vital Medium/High. Reagents: HPA003333.

Contexts: Adrenal gland / Glandular cells; Bronchus / Respiratory epithelial cells; Caudate / Glial cells; Cerebellum / Purkinje cells; Cerebral cortex / Glial cells; Duodenum / Glandular cells; Hippocampus / Glial cells; Kidney / Cells in glomeruli; Kidney / Cells in tubules; Pancreas / Pancreatic endocrine cells; Parathyroid gland / Glandular cells; Rectum / Glandular cells; Skeletal muscle / Myocytes; Skin 1 / Keratinocytes; Skin 2 / Epidermal cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells; Thyroid gland / Glandular cells; Urinary bladder / Urothelial cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 8 Medium/High normal annotations (4 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000124260.

MAGEA4 — Neither

ENSG00000147381 · 26 positive raw rows; 3 Medium/High; 2 Vital Medium/High. Reagents: CAB040535; HPA021942.

Contexts: Adrenal gland / Glandular cells; Bronchus / Respiratory epithelial cells; Caudate / Neuronal cells; Cerebellum / Purkinje cells; Cerebral cortex / Neuronal cells; Colon / Endothelial cells; Colon / Glandular cells; Esophagus / Squamous epithelial cells; Hippocampus / Neuronal cells; Kidney / Cells in tubules; Oral mucosa / Squamous epithelial cells; Pancreas / Exocrine glandular cells; Pancreas / Pancreatic endocrine cells; Parathyroid gland / Glandular cells; Rectum / Glandular cells; Salivary gland / Glandular cells; Skeletal muscle / Myocytes; Skin 1 / Keratinocytes; Skin 1 / Langerhans; Skin 2 / Epidermal cells; Smooth muscle / Smooth muscle cells; Spleen / Cells in red pulp; Thyroid gland / Glandular cells; Urinary bladder / Urothelial cells.

Decision: 3 Medium/High normal annotations (2 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting. The independent OTI1F9 study supports a validated tumor assay and reports a normal panel negative outside reproductive tissues; it does not directly resolve the different HPA021942/CAB040535 neural and epidermal signals. Preserve afami-cel evidence at product scope.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000147381.

MAGEA8 — Neither

ENSG00000156009 · 19 positive raw rows; 2 Medium/High; 1 Vital Medium/High. Reagents: HPA003998.

Contexts: Adipose tissue / Adipocytes; Adrenal gland / Glandular cells; Bronchus / Respiratory epithelial cells; Cerebellum / Cells in granular layer; Cerebellum / Cells in molecular layer; Cerebral cortex / Neuronal cells; Cerebral cortex / Neuropil; Colon / Glandular cells; Hippocampus / Neuronal cells; Kidney / Cells in tubules; Liver / Cholangiocytes; Nasopharynx / Respiratory epithelial cells; Pancreas / Pancreatic endocrine cells; Parathyroid gland / Glandular cells; Rectum / Glandular cells; Small intestine / Glandular cells; Stomach 1 / Glandular cells; Thyroid gland / Glandular cells; Urinary bladder / Urothelial cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 2 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000156009.

MAGEB1 — Neither

ENSG00000214107 · 12 positive raw rows; 7 Medium/High; 2 Vital Medium/High. Reagents: HPA001193; HPA002820.

Contexts: Colon / Glandular cells; Duodenum / Glandular cells; Oral mucosa / Squamous epithelial cells; Parathyroid gland / Glandular cells; Rectum / Glandular cells; Small intestine / Glandular cells; Smooth muscle / Smooth muscle cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells.

Decision: 7 Medium/High normal annotations (2 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000214107.

MAGEB3 — Neither

ENSG00000198798 · 12 positive raw rows; 5 Medium/High; 4 Vital Medium/High. Reagents: HPA072203.

Contexts: Adrenal gland / Glandular cells; Bronchus / Respiratory epithelial cells; Caudate / Neuronal cells; Cerebral cortex / Glial cells; Cerebral cortex / Neuronal cells; Duodenum / Glandular cells; Esophagus / Squamous epithelial cells; Hippocampus / Neuronal cells; Kidney / Cells in tubules; Nasopharynx / Respiratory epithelial cells; Salivary gland / Glandular cells; Small intestine / Glandular cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 5 Medium/High normal annotations (4 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000198798.

MAGEC1 — Neither

ENSG00000155495 · 1 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA004622.

Contexts: Kidney / Cells in tubules.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000155495.

MEIOC — Neither

ENSG00000180336 · 2 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA027266.

Contexts: Bone marrow / Hematopoietic cells; Spleen / Cells in red pulp.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000180336.

MGAT4D — Neither

ENSG00000205301 · 1 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA036523.

Contexts: Oral mucosa / Squamous epithelial cells.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000205301.

MORC1 — Neither

ENSG00000114487 · 12 positive raw rows; 1 Medium/High; 0 Vital Medium/High. Reagents: HPA036413.

Contexts: Adrenal gland / Glandular cells; Colon / Glandular cells; Lung / Alveolar cells; Oral mucosa / Squamous epithelial cells; Rectum / Glandular cells; Skeletal muscle / Myocytes; Skin 1 / Keratinocytes; Skin 1 / Langerhans; Skin 2 / Epidermal cells; Stomach 2 / Glandular cells; Thyroid gland / Glandular cells; Urinary bladder / Urothelial cells.

Decision: 1 Medium/High normal annotations (0 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000114487.

MOV10L1 — Neither

ENSG00000073146 · 16 positive raw rows; 5 Medium/High; 3 Vital Medium/High. Reagents: HPA019034.

Contexts: Adrenal gland / Glandular cells; Caudate / Glial cells; Cerebellum / Cells in granular layer; Cerebral cortex / Neuronal cells; Heart muscle / Cardiomyocytes; Hippocampus / Glial cells; Liver / Hepatocytes; Lung / Macrophages; Pancreas / Pancreatic endocrine cells; Parathyroid gland / Glandular cells; Skin 2 / Epidermal cells; Smooth muscle / Smooth muscle cells; Spleen / Cells in red pulp; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells; Thyroid gland / Glandular cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 5 Medium/High normal annotations (3 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000073146.

MROH2B — Neither

ENSG00000171495 · 15 positive raw rows; 6 Medium/High; 5 Vital Medium/High. Reagents: HPA059457.

Contexts: Adrenal gland / Glandular cells; Bone marrow / Hematopoietic cells; Bronchus / Respiratory epithelial cells; Cerebellum / Purkinje cells; Heart muscle / Cardiomyocytes; Kidney / Cells in tubules; Liver / Hepatocytes; Lung / Alveolar cells; Pancreas / Exocrine glandular cells; Parathyroid gland / Glandular cells; Rectum / Glandular cells; Salivary gland / Glandular cells; Skin 1 / Keratinocytes; Small intestine / Glandular cells; Stomach 1 / Glandular cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 6 Medium/High normal annotations (5 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000171495.

NAA11 — Neither

ENSG00000156269 · 15 positive raw rows; 4 Medium/High; 2 Vital Medium/High. Reagents: HPA035922.

Contexts: Adrenal gland / Glandular cells; Bronchus / Respiratory epithelial cells; Caudate / Neuronal cells; Cerebellum / Cells in granular layer; Colon / Glandular cells; Esophagus / Squamous epithelial cells; Heart muscle / Cardiomyocytes; Nasopharynx / Respiratory epithelial cells; Oral mucosa / Squamous epithelial cells; Skeletal muscle / Myocytes; Skin 1 / Fibroblasts; Skin 1 / Keratinocytes; Skin 1 / Langerhans; Skin 2 / Epidermal cells; Thyroid gland / Glandular cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 4 Medium/High normal annotations (2 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000156269.

NANOS2 — Neither

ENSG00000188425 · 27 positive raw rows; 10 Medium/High; 9 Vital Medium/High. Reagents: HPA014190.

Contexts: Adrenal gland / Glandular cells; Caudate / Glial cells; Caudate / Neuronal cells; Cerebellum / Cells in granular layer; Cerebellum / Cells in molecular layer; Cerebellum / Purkinje cells; Cerebral cortex / Neuronal cells; Cerebral cortex / Neuropil; Duodenum / Glandular cells; Esophagus / Squamous epithelial cells; Heart muscle / Cardiomyocytes; Hippocampus / Glial cells; Hippocampus / Neuronal cells; Kidney / Cells in glomeruli; Kidney / Cells in tubules; Lung / Macrophages; Lymph node / Non-germinal center cells; Pancreas / Pancreatic endocrine cells; Parathyroid gland / Glandular cells; Rectum / Glandular cells; Salivary gland / Glandular cells; Skeletal muscle / Myocytes; Smooth muscle / Smooth muscle cells; Spleen / Cells in red pulp; Stomach 2 / Glandular cells; Thyroid gland / Glandular cells; Urinary bladder / Urothelial cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 10 Medium/High normal annotations (9 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000188425.

NUP210L — Neither

ENSG00000143552 · 47 positive raw rows; 18 Medium/High; 11 Vital Medium/High. Reagents: HPA064245; HPA066707.

Contexts: Adipose tissue / Adipocytes; Adrenal gland / Glandular cells; Bronchus / Respiratory epithelial cells; Cerebellum / Purkinje cells; Cerebral cortex / Endothelial cells; Cerebral cortex / Neuronal cells; Colon / Glandular cells; Duodenum / Glandular cells; Esophagus / Squamous epithelial cells; Heart muscle / Cardiomyocytes; Hippocampus / Neuronal cells; Kidney / Cells in tubules; Lung / Alveolar cells; Lung / Macrophages; Lymph node / Non-germinal center cells; Nasopharynx / Respiratory epithelial cells; Pancreas / Exocrine glandular cells; Pancreas / Pancreatic endocrine cells; Parathyroid gland / Glandular cells; Rectum / Glandular cells; Salivary gland / Glandular cells; Skeletal muscle / Myocytes; Skin 1 / Keratinocytes; Skin 1 / Langerhans; Skin 2 / Epidermal cells; Small intestine / Glandular cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells; Thyroid gland / Glandular cells; Urinary bladder / Urothelial cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 18 Medium/High normal annotations (11 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000143552.

NUTM1 — Neither

ENSG00000184507 · 4 positive raw rows; 1 Medium/High; 0 Vital Medium/High. Reagents: HPA040421.

Contexts: Adrenal gland / Glandular cells; Duodenum / Glandular cells; Esophagus / Squamous epithelial cells; Oral mucosa / Squamous epithelial cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 1 Medium/High normal annotations (0 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000184507.

ODF1 — Neither

ENSG00000155087 · 13 positive raw rows; 8 Medium/High; 7 Vital Medium/High. Reagents: HPA064295.

Contexts: Adrenal gland / Glandular cells; Bronchus / Respiratory epithelial cells; Colon / Glandular cells; Duodenum / Glandular cells; Heart muscle / Cardiomyocytes; Kidney / Cells in tubules; Pancreas / Pancreatic endocrine cells; Rectum / Glandular cells; Salivary gland / Glandular cells; Skeletal muscle / Myocytes; Small intestine / Glandular cells; Stomach 2 / Glandular cells; Thyroid gland / Glandular cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 8 Medium/High normal annotations (7 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000155087.

ODF4 — Neither

ENSG00000184650 · 7 positive raw rows; 2 Medium/High; 0 Vital Medium/High. Reagents: HPA072129.

Contexts: Cerebral cortex / Glial cells; Cerebral cortex / Neuropil; Lymph node / Germinal center cells; Lymph node / Non-germinal center cells; Skeletal muscle / Myocytes; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 2 Medium/High normal annotations (0 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000184650.

OOEP — Neither

ENSG00000203907 · 4 positive raw rows; 1 Medium/High; 1 Vital Medium/High. Reagents: HPA055165.

Contexts: Cerebral cortex / Neuropil; Kidney / Cells in glomeruli; Rectum / Glandular cells; Smooth muscle / Smooth muscle cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 1 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000203907.

PASD1 — Neither

ENSG00000166049 · 25 positive raw rows; 3 Medium/High; 2 Vital Medium/High. Reagents: HPA011122; HPA011152.

Contexts: Adrenal gland / Glandular cells; Bone marrow / Hematopoietic cells; Bronchus / Respiratory epithelial cells; Caudate / Neuronal cells; Cerebellum / Purkinje cells; Colon / Peripheral nerve/ganglion; Duodenum / Glandular cells; Kidney / Cells in tubules; Liver / Hepatocytes; Lung / Macrophages; Lymph node / Germinal center cells; Lymph node / Non-germinal center cells; Nasopharynx / Respiratory epithelial cells; Pancreas / Exocrine glandular cells; Pancreas / Pancreatic endocrine cells; Rectum / Glandular cells; Skin 2 / Epidermal cells; Small intestine / Glandular cells; Spleen / Cells in red pulp; Spleen / Cells in white pulp; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells; Thyroid gland / Glandular cells; Urinary bladder / Urothelial cells.

Decision: 3 Medium/High normal annotations (2 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000166049.

PDCL2 — Neither

ENSG00000163440 · 2 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA048260.

Contexts: Bronchus / Respiratory epithelial cells; Nasopharynx / Respiratory epithelial cells.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000163440.

PDHA2 — Neither

ENSG00000163114 · 93 positive raw rows; 57 Medium/High; 32 Vital Medium/High. Reagents: HPA047487; HPA047864; HPA063053.

Contexts: Adipose tissue / Adipocytes; Adrenal gland / Glandular cells; Bone marrow / Hematopoietic cells; Bronchus / Respiratory epithelial cells; Caudate / Neuronal cells; Cerebellum / Cells in granular layer; Cerebellum / Cells in molecular layer; Cerebellum / Purkinje cells; Cerebral cortex / Endothelial cells; Cerebral cortex / Glial cells; Cerebral cortex / Neuronal cells; Cerebral cortex / Neuropil; Colon / Endothelial cells; Colon / Glandular cells; Colon / Peripheral nerve/ganglion; Duodenum / Glandular cells; Esophagus / Squamous epithelial cells; Heart muscle / Cardiomyocytes; Hippocampus / Glial cells; Hippocampus / Neuronal cells; Kidney / Cells in glomeruli; Kidney / Cells in tubules; Liver / Cholangiocytes; Liver / Hepatocytes; Lung / Alveolar cells; Lung / Macrophages; Lymph node / Germinal center cells; Lymph node / Non-germinal center cells; Nasopharynx / Respiratory epithelial cells; Oral mucosa / Squamous epithelial cells; Pancreas / Exocrine glandular cells; Pancreas / Pancreatic endocrine cells; Parathyroid gland / Glandular cells; Rectum / Glandular cells; Salivary gland / Glandular cells; Skeletal muscle / Myocytes; Skin 1 / Fibroblasts; Skin 1 / Keratinocytes; Skin 1 / Langerhans; Skin 2 / Epidermal cells; Small intestine / Glandular cells; Smooth muscle / Smooth muscle cells; Spleen / Cells in red pulp; Spleen / Cells in white pulp; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells; Thyroid gland / Glandular cells; Urinary bladder / Urothelial cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 57 Medium/High normal annotations (32 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000163114.

PGK2 — Neither

ENSG00000170950 · 31 positive raw rows; 10 Medium/High; 5 Vital Medium/High. Reagents: HPA045385; HPA073644; HPA073656.

Contexts: Adrenal gland / Glandular cells; Bronchus / Respiratory epithelial cells; Caudate / Neuronal cells; Cerebral cortex / Glial cells; Cerebral cortex / Neuronal cells; Cerebral cortex / Neuropil; Colon / Endothelial cells; Colon / Glandular cells; Duodenum / Glandular cells; Esophagus / Squamous epithelial cells; Heart muscle / Cardiomyocytes; Kidney / Cells in tubules; Liver / Hepatocytes; Lung / Macrophages; Nasopharynx / Respiratory epithelial cells; Oral mucosa / Squamous epithelial cells; Pancreas / Pancreatic endocrine cells; Parathyroid gland / Glandular cells; Rectum / Glandular cells; Salivary gland / Glandular cells; Skin 1 / Fibroblasts; Skin 1 / Keratinocytes; Small intestine / Glandular cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells; Thyroid gland / Glandular cells; Urinary bladder / Urothelial cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. 10 Medium/High normal annotations (5 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000170950.

PKDREJ — Neither

ENSG00000130943 · 5 positive raw rows; 1 Medium/High; 1 Vital Medium/High. Reagents: HPA034587.

Contexts: Bronchus / Respiratory epithelial cells; Duodenum / Glandular cells; Lung / Macrophages; Rectum / Glandular cells; Small intestine / Glandular cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 1 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000130943.

PLAC1 — Neither

ENSG00000170965 · 6 positive raw rows; 2 Medium/High; 2 Vital Medium/High. Reagents: HPA063425.

Contexts: Adrenal gland / Glandular cells; Caudate / Neuronal cells; Cerebral cortex / Endothelial cells; Cerebral cortex / Neuronal cells; Hippocampus / Neuronal cells; Kidney / Cells in tubules.

Decision: 2 Medium/High normal annotations (2 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000170965.

POM121L12 — Neither

ENSG00000221900 · 11 positive raw rows; 3 Medium/High; 3 Vital Medium/High. Reagents: HPA027836.

Contexts: Adrenal gland / Glandular cells; Cerebral cortex / Neuropil; Duodenum / Glandular cells; Kidney / Cells in tubules; Liver / Hepatocytes; Parathyroid gland / Glandular cells; Rectum / Glandular cells; Salivary gland / Glandular cells; Small intestine / Glandular cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 3 Medium/High normal annotations (3 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000221900.

PRAME — Unsafe

ENSG00000185686 · 3 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA045153.

Contexts: Colon / Glandular cells; Rectum / Glandular cells; Small intestine / Glandular cells.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting. A separate gene-resolved publication reports adrenal-cortical protein; that accepted finding takes precedence and makes the final gene category Unsafe.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000185686, review-20261025-PRAME-adrenal.

PRDM7 — Neither

ENSG00000126856 · 3 positive raw rows; 2 Medium/High; 0 Vital Medium/High. Reagents: HPA059944.

Contexts: Colon / Glandular cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 2 Medium/High normal annotations (0 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000126856.

PRKACG — Neither

ENSG00000165059 · 15 positive raw rows; 4 Medium/High; 3 Vital Medium/High. Reagents: CAB004530.

Contexts: Adipose tissue / Adipocytes; Adrenal gland / Glandular cells; Bone marrow / Hematopoietic cells; Bronchus / Respiratory epithelial cells; Colon / Peripheral nerve/ganglion; Kidney / Cells in tubules; Lung / Macrophages; Lymph node / Non-germinal center cells; Pancreas / Exocrine glandular cells; Parathyroid gland / Glandular cells; Spleen / Cells in red pulp; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells; Thyroid gland / Glandular cells; Urinary bladder / Urothelial cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 4 Medium/High normal annotations (3 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000165059.

PRSS37 — Neither

ENSG00000165076 · 4 positive raw rows; 1 Medium/High; 0 Vital Medium/High. Reagents: HPA020541.

Contexts: Heart muscle / Cardiomyocytes; Kidney / Cells in tubules; Salivary gland / Glandular cells; Stomach 2 / Glandular cells.

Decision: 1 Medium/High normal annotations (0 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000165076.

PRSS54 — Neither

ENSG00000103023 · 3 positive raw rows; 1 Medium/High; 1 Vital Medium/High. Reagents: HPA041549.

Contexts: Adrenal gland / Glandular cells; Duodenum / Glandular cells; Small intestine / Glandular cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 1 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000103023.

PSG1 — Neither

ENSG00000231924 · 19 positive raw rows; 7 Medium/High; 1 Vital Medium/High. Reagents: HPA046327.

Contexts: Adrenal gland / Glandular cells; Bronchus / Respiratory epithelial cells; Cerebral cortex / Endothelial cells; Cerebral cortex / Glial cells; Colon / Endothelial cells; Colon / Glandular cells; Colon / Peripheral nerve/ganglion; Esophagus / Squamous epithelial cells; Kidney / Cells in glomeruli; Kidney / Cells in tubules; Liver / Hepatocytes; Lung / Macrophages; Nasopharynx / Respiratory epithelial cells; Rectum / Glandular cells; Skin 1 / Fibroblasts; Smooth muscle / Smooth muscle cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells; Thyroid gland / Glandular cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 7 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000231924.

PSG11 — Neither

ENSG00000243130 · 24 positive raw rows; 11 Medium/High; 3 Vital Medium/High. Reagents: HPA042240; HPA046327.

Contexts: Adrenal gland / Glandular cells; Bone marrow / Hematopoietic cells; Bronchus / Respiratory epithelial cells; Cerebral cortex / Endothelial cells; Cerebral cortex / Glial cells; Colon / Endothelial cells; Colon / Glandular cells; Colon / Peripheral nerve/ganglion; Esophagus / Squamous epithelial cells; Kidney / Cells in glomeruli; Kidney / Cells in tubules; Liver / Hepatocytes; Lung / Macrophages; Nasopharynx / Respiratory epithelial cells; Pancreas / Exocrine glandular cells; Rectum / Glandular cells; Skin 1 / Fibroblasts; Smooth muscle / Smooth muscle cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells; Thyroid gland / Glandular cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 11 Medium/High normal annotations (3 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000243130.

PSG3 — Neither

ENSG00000221826 · 19 positive raw rows; 7 Medium/High; 1 Vital Medium/High. Reagents: HPA046327.

Contexts: Adrenal gland / Glandular cells; Bronchus / Respiratory epithelial cells; Cerebral cortex / Endothelial cells; Cerebral cortex / Glial cells; Colon / Endothelial cells; Colon / Glandular cells; Colon / Peripheral nerve/ganglion; Esophagus / Squamous epithelial cells; Kidney / Cells in glomeruli; Kidney / Cells in tubules; Liver / Hepatocytes; Lung / Macrophages; Nasopharynx / Respiratory epithelial cells; Rectum / Glandular cells; Skin 1 / Fibroblasts; Smooth muscle / Smooth muscle cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells; Thyroid gland / Glandular cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 7 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000221826.

PSG6 — Neither

ENSG00000170848 · 19 positive raw rows; 7 Medium/High; 1 Vital Medium/High. Reagents: HPA046327.

Contexts: Adrenal gland / Glandular cells; Bronchus / Respiratory epithelial cells; Cerebral cortex / Endothelial cells; Cerebral cortex / Glial cells; Colon / Endothelial cells; Colon / Glandular cells; Colon / Peripheral nerve/ganglion; Esophagus / Squamous epithelial cells; Kidney / Cells in glomeruli; Kidney / Cells in tubules; Liver / Hepatocytes; Lung / Macrophages; Nasopharynx / Respiratory epithelial cells; Rectum / Glandular cells; Skin 1 / Fibroblasts; Smooth muscle / Smooth muscle cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells; Thyroid gland / Glandular cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 7 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000170848.

PSG7 — Neither

ENSG00000221878 · 19 positive raw rows; 7 Medium/High; 1 Vital Medium/High. Reagents: HPA046327.

Contexts: Adrenal gland / Glandular cells; Bronchus / Respiratory epithelial cells; Cerebral cortex / Endothelial cells; Cerebral cortex / Glial cells; Colon / Endothelial cells; Colon / Glandular cells; Colon / Peripheral nerve/ganglion; Esophagus / Squamous epithelial cells; Kidney / Cells in glomeruli; Kidney / Cells in tubules; Liver / Hepatocytes; Lung / Macrophages; Nasopharynx / Respiratory epithelial cells; Rectum / Glandular cells; Skin 1 / Fibroblasts; Smooth muscle / Smooth muscle cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells; Thyroid gland / Glandular cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 7 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000221878.

PSG8 — Neither

ENSG00000124467 · 19 positive raw rows; 7 Medium/High; 1 Vital Medium/High. Reagents: HPA046327.

Contexts: Adrenal gland / Glandular cells; Bronchus / Respiratory epithelial cells; Cerebral cortex / Endothelial cells; Cerebral cortex / Glial cells; Colon / Endothelial cells; Colon / Glandular cells; Colon / Peripheral nerve/ganglion; Esophagus / Squamous epithelial cells; Kidney / Cells in glomeruli; Kidney / Cells in tubules; Liver / Hepatocytes; Lung / Macrophages; Nasopharynx / Respiratory epithelial cells; Rectum / Glandular cells; Skin 1 / Fibroblasts; Smooth muscle / Smooth muscle cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells; Thyroid gland / Glandular cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 7 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000124467.

PSG9 — Neither

ENSG00000183668 · 19 positive raw rows; 7 Medium/High; 1 Vital Medium/High. Reagents: HPA046327.

Contexts: Adrenal gland / Glandular cells; Bronchus / Respiratory epithelial cells; Cerebral cortex / Endothelial cells; Cerebral cortex / Glial cells; Colon / Endothelial cells; Colon / Glandular cells; Colon / Peripheral nerve/ganglion; Esophagus / Squamous epithelial cells; Kidney / Cells in glomeruli; Kidney / Cells in tubules; Liver / Hepatocytes; Lung / Macrophages; Nasopharynx / Respiratory epithelial cells; Rectum / Glandular cells; Skin 1 / Fibroblasts; Smooth muscle / Smooth muscle cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells; Thyroid gland / Glandular cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 7 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000183668.

RAD21L1 — Neither

ENSG00000244588 · 23 positive raw rows; 7 Medium/High; 3 Vital Medium/High. Reagents: HPA053282.

Contexts: Adrenal gland / Glandular cells; Bone marrow / Hematopoietic cells; Colon / Endothelial cells; Colon / Glandular cells; Colon / Peripheral nerve/ganglion; Duodenum / Glandular cells; Esophagus / Squamous epithelial cells; Heart muscle / Cardiomyocytes; Kidney / Cells in tubules; Liver / Hepatocytes; Oral mucosa / Squamous epithelial cells; Parathyroid gland / Glandular cells; Rectum / Glandular cells; Skeletal muscle / Myocytes; Skin 1 / Fibroblasts; Skin 1 / Keratinocytes; Skin 1 / Langerhans; Skin 2 / Epidermal cells; Small intestine / Glandular cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells; Thyroid gland / Glandular cells; Urinary bladder / Urothelial cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 7 Medium/High normal annotations (3 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000244588.

RBMXL2 — Neither

ENSG00000170748 · 23 positive raw rows; 15 Medium/High; 11 Vital Medium/High. Reagents: HPA038912.

Contexts: Adrenal gland / Glandular cells; Bronchus / Respiratory epithelial cells; Cerebral cortex / Endothelial cells; Cerebral cortex / Neuronal cells; Colon / Endothelial cells; Colon / Glandular cells; Duodenum / Glandular cells; Heart muscle / Cardiomyocytes; Kidney / Cells in glomeruli; Kidney / Cells in tubules; Liver / Cholangiocytes; Liver / Hepatocytes; Lung / Macrophages; Nasopharynx / Respiratory epithelial cells; Rectum / Glandular cells; Salivary gland / Glandular cells; Skeletal muscle / Myocytes; Small intestine / Glandular cells; Smooth muscle / Smooth muscle cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells; Thyroid gland / Glandular cells; Urinary bladder / Urothelial cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. 15 Medium/High normal annotations (11 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000170748.

RBMY1A1 — Neither

ENSG00000234414 · 2 positive raw rows; 1 Medium/High; 1 Vital Medium/High. Reagents: HPA053147.

Contexts: Oral mucosa / Squamous epithelial cells; Pancreas / Exocrine glandular cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. 1 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000234414.

RBMY1B — Neither

ENSG00000242875 · 2 positive raw rows; 1 Medium/High; 1 Vital Medium/High. Reagents: HPA053147.

Contexts: Oral mucosa / Squamous epithelial cells; Pancreas / Exocrine glandular cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. 1 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000242875.

RBMY1D — Neither

ENSG00000244395 · 2 positive raw rows; 1 Medium/High; 1 Vital Medium/High. Reagents: HPA053147.

Contexts: Oral mucosa / Squamous epithelial cells; Pancreas / Exocrine glandular cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. 1 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000244395.

RBMY1E — Neither

ENSG00000242389 · 2 positive raw rows; 1 Medium/High; 1 Vital Medium/High. Reagents: HPA053147.

Contexts: Oral mucosa / Squamous epithelial cells; Pancreas / Exocrine glandular cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 1 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000242389.

RBMY1F — Neither

ENSG00000169800 · 2 positive raw rows; 1 Medium/High; 1 Vital Medium/High. Reagents: HPA053147.

Contexts: Oral mucosa / Squamous epithelial cells; Pancreas / Exocrine glandular cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 1 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000169800.

RBMY1J — Neither

ENSG00000226941 · 2 positive raw rows; 1 Medium/High; 1 Vital Medium/High. Reagents: HPA053147.

Contexts: Oral mucosa / Squamous epithelial cells; Pancreas / Exocrine glandular cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. 1 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000226941.

RHOXF2 — Neither

ENSG00000131721 · 1 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: CAB020794.

Contexts: Skeletal muscle / Myocytes.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000131721.

RIMBP3 — Neither

ENSG00000275793 · 2 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA001183.

Contexts: Cerebellum / Purkinje cells; Cerebral cortex / Glial cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000275793.

RIMBP3C — Neither

ENSG00000183246 · 2 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA001183.

Contexts: Cerebellum / Purkinje cells; Cerebral cortex / Glial cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000183246.

RNASE12 — Neither

ENSG00000258436 · 1 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA044175.

Contexts: Small intestine / Glandular cells.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000258436.

RSPH6A — Neither

ENSG00000104941 · 3 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA045382.

Contexts: Adrenal gland / Glandular cells; Duodenum / Glandular cells; Small intestine / Glandular cells.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000104941.

SAGE1 — Neither

ENSG00000181433 · 30 positive raw rows; 9 Medium/High; 4 Vital Medium/High. Reagents: HPA003033; HPA003208.

Contexts: Adipose tissue / Adipocytes; Bone marrow / Hematopoietic cells; Bronchus / Respiratory epithelial cells; Caudate / Neuronal cells; Cerebellum / Purkinje cells; Colon / Peripheral nerve/ganglion; Duodenum / Glandular cells; Heart muscle / Cardiomyocytes; Hippocampus / Neuronal cells; Lung / Macrophages; Nasopharynx / Respiratory epithelial cells; Pancreas / Exocrine glandular cells; Pancreas / Pancreatic endocrine cells; Rectum / Glandular cells; Salivary gland / Glandular cells; Skin 1 / Keratinocytes; Smooth muscle / Smooth muscle cells; Spleen / Cells in red pulp; Spleen / Cells in white pulp; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells; Thyroid gland / Glandular cells; Urinary bladder / Urothelial cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 9 Medium/High normal annotations (4 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000181433.

SEL1L2 — Neither

ENSG00000101251 · 1 positive raw rows; 1 Medium/High; 1 Vital Medium/High. Reagents: HPA059121.

Contexts: Cerebellum / Purkinje cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 1 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000101251.

SLCO6A1 — Neither

ENSG00000205359 · 4 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA054126.

Contexts: Kidney / Cells in tubules; Lymph node / Non-germinal center cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000205359.

SMC1B — Neither

ENSG00000077935 · 1 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA001500.

Contexts: Liver / Hepatocytes.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000077935.

SMIM21 — Neither

ENSG00000206026 · 7 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA041686.

Contexts: Bone marrow / Hematopoietic cells; Heart muscle / Cardiomyocytes; Parathyroid gland / Glandular cells; Skeletal muscle / Myocytes; Skin 1 / Keratinocytes; Skin 2 / Epidermal cells; Spleen / Cells in red pulp.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000206026.

SOX30 — Neither

ENSG00000039600 · 40 positive raw rows; 8 Medium/High; 5 Vital Medium/High. Reagents: CAB009382; HPA006159.

Contexts: Adipose tissue / Adipocytes; Adrenal gland / Glandular cells; Bone marrow / Hematopoietic cells; Bronchus / Respiratory epithelial cells; Caudate / Neuronal cells; Cerebellum / Cells in molecular layer; Cerebellum / Purkinje cells; Cerebral cortex / Neuronal cells; Cerebral cortex / Neuropil; Colon / Glandular cells; Duodenum / Glandular cells; Esophagus / Squamous epithelial cells; Heart muscle / Cardiomyocytes; Hippocampus / Neuronal cells; Kidney / Cells in tubules; Liver / Hepatocytes; Lung / Macrophages; Nasopharynx / Respiratory epithelial cells; Oral mucosa / Squamous epithelial cells; Pancreas / Exocrine glandular cells; Pancreas / Pancreatic endocrine cells; Parathyroid gland / Glandular cells; Rectum / Glandular cells; Skeletal muscle / Myocytes; Skin 1 / Keratinocytes; Skin 1 / Langerhans; Small intestine / Glandular cells; Smooth muscle / Smooth muscle cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells; Thyroid gland / Glandular cells; Urinary bladder / Urothelial cells.

Decision: 8 Medium/High normal annotations (5 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000039600.

SPACA1 — Neither

ENSG00000118434 · 12 positive raw rows; 5 Medium/High; 4 Vital Medium/High. Reagents: HPA026744; HPA043297.

Contexts: Bone marrow / Hematopoietic cells; Bronchus / Respiratory epithelial cells; Colon / Glandular cells; Duodenum / Glandular cells; Heart muscle / Cardiomyocytes; Lung / Macrophages; Lymph node / Non-germinal center cells; Nasopharynx / Respiratory epithelial cells; Salivary gland / Glandular cells; Skeletal muscle / Myocytes; Small intestine / Glandular cells; Smooth muscle / Smooth muscle cells.

Decision: 5 Medium/High normal annotations (4 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000118434.

SPACA4 — Neither

ENSG00000177202 · 1 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA041927.

Contexts: Pancreas / Exocrine glandular cells.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000177202.

SPACA5 — Neither

ENSG00000171489 · 4 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA044747.

Contexts: Caudate / Neuronal cells; Heart muscle / Cardiomyocytes; Kidney / Cells in tubules; Stomach 2 / Glandular cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000171489.

SPAM1 — Neither

ENSG00000106304 · 5 positive raw rows; 2 Medium/High; 2 Vital Medium/High. Reagents: HPA017984.

Contexts: Bronchus / Respiratory epithelial cells; Cerebral cortex / Neuropil; Duodenum / Glandular cells; Skin 2 / Epidermal cells; Small intestine / Glandular cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 2 Medium/High normal annotations (2 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000106304.

SPATA12 — Neither

ENSG00000186451 · 1 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA075578.

Contexts: Kidney / Cells in tubules.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000186451.

SPATA16 — Neither

ENSG00000144962 · 2 positive raw rows; 1 Medium/High; 1 Vital Medium/High. Reagents: HPA037884.

Contexts: Cerebellum / Cells in molecular layer; Cerebral cortex / Neuronal cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 1 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000144962.

SPATA19 — Neither

ENSG00000166118 · 2 positive raw rows; 1 Medium/High; 0 Vital Medium/High. Reagents: HPA040082.

Contexts: Salivary gland / Glandular cells; Stomach 2 / Glandular cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 1 Medium/High normal annotations (0 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000166118.

SPATA3 — Neither

ENSG00000173699 · 3 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA018254.

Contexts: Lung / Macrophages; Pancreas / Pancreatic endocrine cells; Skin 2 / Epidermal cells.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000173699.

SPATS1 — Neither

ENSG00000249481 · 22 positive raw rows; 6 Medium/High; 5 Vital Medium/High. Reagents: HPA049722.

Contexts: Cerebellum / Cells in granular layer; Cerebellum / Purkinje cells; Cerebral cortex / Neuronal cells; Cerebral cortex / Neuropil; Colon / Glandular cells; Colon / Peripheral nerve/ganglion; Duodenum / Glandular cells; Hippocampus / Neuronal cells; Kidney / Cells in tubules; Lymph node / Non-germinal center cells; Nasopharynx / Respiratory epithelial cells; Oral mucosa / Squamous epithelial cells; Pancreas / Exocrine glandular cells; Pancreas / Pancreatic endocrine cells; Rectum / Glandular cells; Salivary gland / Glandular cells; Skeletal muscle / Myocytes; Small intestine / Glandular cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells; Thyroid gland / Glandular cells; Urinary bladder / Urothelial cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 6 Medium/High normal annotations (5 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000249481.

SPDYE4 — Neither

ENSG00000183318 · 2 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA051750.

Contexts: Kidney / Cells in tubules; Thyroid gland / Glandular cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000183318.

SPMIP9 — Neither

ENSG00000172073 · 10 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA043987.

Contexts: Bone marrow / Hematopoietic cells; Bronchus / Respiratory epithelial cells; Duodenum / Glandular cells; Esophagus / Squamous epithelial cells; Lymph node / Germinal center cells; Oral mucosa / Squamous epithelial cells; Rectum / Glandular cells; Skin 2 / Epidermal cells; Small intestine / Glandular cells; Stomach 2 / Glandular cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000172073.

STPG4 — Neither

ENSG00000239605 · 18 positive raw rows; 6 Medium/High; 5 Vital Medium/High. Reagents: HPA052691.

Contexts: Bone marrow / Hematopoietic cells; Bronchus / Respiratory epithelial cells; Cerebellum / Purkinje cells; Cerebral cortex / Endothelial cells; Cerebral cortex / Neuronal cells; Colon / Glandular cells; Colon / Peripheral nerve/ganglion; Duodenum / Glandular cells; Hippocampus / Neuronal cells; Kidney / Cells in tubules; Lymph node / Non-germinal center cells; Nasopharynx / Respiratory epithelial cells; Pancreas / Exocrine glandular cells; Rectum / Glandular cells; Small intestine / Glandular cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells; Thyroid gland / Glandular cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 6 Medium/High normal annotations (5 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000239605.

SUN5 — Neither

ENSG00000167098 · 2 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA048529.

Contexts: Rectum / Glandular cells; Smooth muscle / Smooth muscle cells.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000167098.

SYCP1 — Neither

ENSG00000198765 · 2 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA021083.

Contexts: Bronchus / Respiratory epithelial cells; Hippocampus / Neuronal cells.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000198765.

TBC1D21 — Neither

ENSG00000167139 · 8 positive raw rows; 2 Medium/High; 2 Vital Medium/High. Reagents: HPA043319.

Contexts: Adrenal gland / Glandular cells; Colon / Glandular cells; Heart muscle / Cardiomyocytes; Oral mucosa / Squamous epithelial cells; Rectum / Glandular cells; Skeletal muscle / Myocytes; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 2 Medium/High normal annotations (2 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000167139.

TCP11 — Neither

ENSG00000124678 · 2 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA048311.

Contexts: Duodenum / Glandular cells; Small intestine / Glandular cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000124678.

TEX13A — Neither

ENSG00000268629 · 1 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA072257.

Contexts: Skeletal muscle / Myocytes.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000268629.

TEX14 — Neither

ENSG00000121101 · 3 positive raw rows; 1 Medium/High; 1 Vital Medium/High. Reagents: HPA077020.

Contexts: Kidney / Cells in tubules; Salivary gland / Glandular cells; Urinary bladder / Urothelial cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 1 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000121101.

TEX15 — Neither

ENSG00000133863 · 8 positive raw rows; 1 Medium/High; 1 Vital Medium/High. Reagents: HPA036800.

Contexts: Caudate / Neuronal cells; Cerebral cortex / Neuronal cells; Hippocampus / Neuronal cells; Kidney / Cells in tubules; Nasopharynx / Respiratory epithelial cells; Rectum / Glandular cells; Small intestine / Glandular cells; Urinary bladder / Urothelial cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 1 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000133863.

TEX19 — Neither

ENSG00000182459 · 4 positive raw rows; 1 Medium/High; 1 Vital Medium/High. Reagents: HPA054577.

Contexts: Adrenal gland / Glandular cells; Colon / Glandular cells; Duodenum / Glandular cells; Small intestine / Glandular cells.

Decision: 1 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000182459.

TEX44 — Neither

ENSG00000177673 · 13 positive raw rows; 6 Medium/High; 2 Vital Medium/High. Reagents: HPA049917; HPA056433.

Contexts: Adrenal gland / Glandular cells; Cerebral cortex / Neuronal cells; Colon / Glandular cells; Duodenum / Glandular cells; Kidney / Cells in glomeruli; Kidney / Cells in tubules; Parathyroid gland / Glandular cells; Rectum / Glandular cells; Skeletal muscle / Myocytes; Small intestine / Glandular cells; Stomach 2 / Glandular cells; Urinary bladder / Urothelial cells.

Decision: 6 Medium/High normal annotations (2 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000177673.

TGIF2LX — Neither

ENSG00000153779 · 2 positive raw rows; 2 Medium/High; 2 Vital Medium/High. Reagents: HPA034543.

Contexts: Pancreas / Exocrine glandular cells; Pancreas / Pancreatic endocrine cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 2 Medium/High normal annotations (2 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000153779.

TMCO5A — Neither

ENSG00000166069 · 4 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA056530.

Contexts: Bronchus / Respiratory epithelial cells; Kidney / Cells in tubules; Stomach 1 / Glandular cells; Urinary bladder / Urothelial cells.

Decision: Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000166069.

TMEM210 — Neither

ENSG00000185863 · 2 positive raw rows; 1 Medium/High; 1 Vital Medium/High. Reagents: HPA066907.

Contexts: Adrenal gland / Glandular cells; Stomach 2 / Glandular cells.

Decision: 1 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000185863.

TSBP1 — Neither

ENSG00000204296 · 8 positive raw rows; 6 Medium/High; 6 Vital Medium/High. Reagents: HPA057426.

Contexts: Adrenal gland / Glandular cells; Bone marrow / Hematopoietic cells; Duodenum / Glandular cells; Kidney / Cells in glomeruli; Kidney / Cells in tubules; Rectum / Glandular cells; Skin 2 / Epidermal cells; Small intestine / Glandular cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 6 Medium/High normal annotations (6 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000204296.

TSPY1 — Neither

ENSG00000258992 · 3 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA049384.

Contexts: Adrenal gland / Glandular cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000258992.

TSPY10 — Neither

ENSG00000236424 · 3 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA049384.

Contexts: Adrenal gland / Glandular cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000236424.

TSPY2 — Neither

ENSG00000168757 · 3 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA049384.

Contexts: Adrenal gland / Glandular cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000168757.

TSPY3 — Neither

ENSG00000228927 · 3 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA049384.

Contexts: Adrenal gland / Glandular cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000228927.

TSPY4 — Neither

ENSG00000233803 · 3 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA049384.

Contexts: Adrenal gland / Glandular cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000233803.

TSPY8 — Neither

ENSG00000229549 · 3 positive raw rows; 0 Medium/High; 0 Vital Medium/High. Reagents: HPA049384.

Contexts: Adrenal gland / Glandular cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. Only Low raw normal annotations remain; faint intensity alone is not evidence that staining is nonspecific. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000229549.

TSPYL6 — Neither

ENSG00000178021 · 14 positive raw rows; 7 Medium/High; 2 Vital Medium/High. Reagents: HPA034699; HPA034700.

Contexts: Bronchus / Respiratory epithelial cells; Cerebellum / Purkinje cells; Colon / Glandular cells; Duodenum / Glandular cells; Lung / Macrophages; Lymph node / Germinal center cells; Lymph node / Non-germinal center cells; Pancreas / Exocrine glandular cells; Rectum / Glandular cells; Skin 1 / Keratinocytes; Skin 2 / Epidermal cells; Small intestine / Glandular cells; Spleen / Cells in red pulp; Thyroid gland / Glandular cells.

Decision: 7 Medium/High normal annotations (2 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000178021.

TSSK1B — Neither

ENSG00000212122 · 1 positive raw rows; 1 Medium/High; 1 Vital Medium/High. Reagents: HPA027827.

Contexts: Bone marrow / Hematopoietic cells.

Decision: 1 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000212122.

TTC23L — Neither

ENSG00000205838 · 20 positive raw rows; 3 Medium/High; 3 Vital Medium/High. Reagents: HPA037807.

Contexts: Adrenal gland / Glandular cells; Bronchus / Respiratory epithelial cells; Cerebellum / Purkinje cells; Cerebral cortex / Neuronal cells; Colon / Endothelial cells; Colon / Glandular cells; Colon / Peripheral nerve/ganglion; Duodenum / Glandular cells; Heart muscle / Cardiomyocytes; Hippocampus / Neuronal cells; Kidney / Cells in tubules; Liver / Hepatocytes; Nasopharynx / Respiratory epithelial cells; Oral mucosa / Squamous epithelial cells; Pancreas / Exocrine glandular cells; Rectum / Glandular cells; Small intestine / Glandular cells; Stomach 1 / Glandular cells; Stomach 2 / Glandular cells; Urinary bladder / Urothelial cells.

Decision: 3 Medium/High normal annotations (3 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000205838.

TTLL13 — Neither

ENSG00000213471 · 1 positive raw rows; 1 Medium/High; 1 Vital Medium/High. Reagents: HPA041305.

Contexts: Adrenal gland / Glandular cells.

Decision: 1 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000213471.

UBQLN3 — Neither

ENSG00000175520 · 3 positive raw rows; 1 Medium/High; 0 Vital Medium/High. Reagents: HPA020547; HPA062018.

Contexts: Colon / Endothelial cells; Heart muscle / Cardiomyocytes; Skin 2 / Epidermal cells.

Decision: 1 Medium/High normal annotations (0 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000175520.

USP26 — Neither

ENSG00000134588 · 2 positive raw rows; 1 Medium/High; 0 Vital Medium/High. Reagents: HPA027310.

Contexts: Lymph node / Non-germinal center cells; Pancreas / Exocrine glandular cells.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 1 Medium/High normal annotations (0 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000134588.

VCX — Neither

ENSG00000182583 · 5 positive raw rows; 1 Medium/High; 1 Vital Medium/High. Reagents: HPA044996.

Contexts: Adrenal gland / Glandular cells; Kidney / Cells in tubules; Liver / Hepatocytes; Pancreas / Exocrine glandular cells; Small intestine / Glandular cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. 1 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000182583.

VCX3A — Neither

ENSG00000169059 · 5 positive raw rows; 1 Medium/High; 1 Vital Medium/High. Reagents: HPA044996.

Contexts: Adrenal gland / Glandular cells; Kidney / Cells in tubules; Liver / Hepatocytes; Pancreas / Exocrine glandular cells; Small intestine / Glandular cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. 1 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000169059.

VCX3B — Neither

ENSG00000205642 · 5 positive raw rows; 1 Medium/High; 1 Vital Medium/High. Reagents: HPA044996.

Contexts: Adrenal gland / Glandular cells; Kidney / Cells in tubules; Liver / Hepatocytes; Pancreas / Exocrine glandular cells; Small intestine / Glandular cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. 1 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000205642.

VCY — Neither

ENSG00000129864 · 5 positive raw rows; 1 Medium/High; 1 Vital Medium/High. Reagents: HPA044996.

Contexts: Adrenal gland / Glandular cells; Kidney / Cells in tubules; Liver / Hepatocytes; Pancreas / Exocrine glandular cells; Small intestine / Glandular cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. 1 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000129864.

VCY1B — Neither

ENSG00000129862 · 5 positive raw rows; 1 Medium/High; 1 Vital Medium/High. Reagents: HPA044996.

Contexts: Adrenal gland / Glandular cells; Kidney / Cells in tubules; Liver / Hepatocytes; Pancreas / Exocrine glandular cells; Small intestine / Glandular cells.

Decision: The source warns that the reagent targets multiple genes; a family signal cannot prove which locus produces the normal protein. 1 Medium/High normal annotations (1 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000129862.

ZCCHC13 — Neither

ENSG00000187969 · 3 positive raw rows; 1 Medium/High; 0 Vital Medium/High. Reagents: HPA003382.

Contexts: Lymph node / Germinal center cells; Lymph node / Non-germinal center cells; Spleen / Cells in white pulp.

Decision: The profile discusses presumed off-target binding, but does not provide a specimen-and-reagent-specific resolution of every retained normal signal. 1 Medium/High normal annotations (0 in Vital compartments) remain specificity conflicts. The curated negative profile and passing RNA screen do not identify the molecule responsible for these raw stains. This evidence does not establish clinical toxicity, but is insufficient to clear unrestricted gene-level targeting.

To reconsider: Resolve the named normal-cell signal using identity-specific endogenous protein or reagent validation; quantify any confirmed normal expression. A trial or another negative bulk atlas alone is not a rebuttal.

Pinned primary data. Review records: ihc-20261025-ENSG00000187969.

Reproduce

Run python scripts/build_cta_adjudication_report.py after rebuilding the current policy. This renders reviewed records; it does not perform new adjudication. Checksums.