Candidate follow-up record
Reviewed 24 October 2026 by Codex during the follow-up to PR #618. This is an implementation/evidence review, not an independent clinical adjudication. These records never override the general classification rules.
Report · Full follow-up CSV · Measured high RNA · All context maxima · Pinned source URLs and checksums
ACRBP
Neither → Unsafe / High RNA. Observed RNA above 30 TPM or nTPM outside explicitly permitted reproductive/disposable contexts; research exclusion, not proven clinical toxicity
Maximum outside explicitly permitted contexts: 5316.5 nTPM and 56.543 TPM (separate units). Reproductive bulk maximum: 275.6 nTPM.
Open question: Does the broad immune and platelet RNA represent endogenous ACRBP expression?
Evidence needed: Resolve normal-cell RNA identity and reliable local protein evidence before changing the general exclusion.
Limits: The retracted PMID 35463688 is excluded; the decision uses pinned RNA. Platelet RNA does not establish peptide presentation.
High normal RNA findings: dice_m2: blood/M2, max 39.1126 TPM, 12 observations >30; hpa_immune_cell: blood/non-classical monocyte, max 31.2 nTPM, 1 observations >30; hpa_immune_cell_samples: blood/non-classical monocyte, max 56.5427 TPM, 1 observations >30; hpa_immune_cell_samples: blood/non-classical monocyte, max 77.8462 nTPM, 1 observations >30; hpa_immune_monaco: blood/intermediate monocyte, max 30.6 TPM, 1 observations >30; hpa_immune_monaco: blood/non-classical monocyte, max 37.5 TPM, 1 observations >30; hpa_single_cell_tissue: pbmc/platelets, max 5316.5 nTPM, 1 observations >30
Immune RNA findings: DICE B_CELL_NAIVE (unstimulated): 77/91 values ≥5 TPM, max 13.4406; DICE MONOCYTES (unstimulated): 91/91 values ≥5 TPM, max 20.75; DICE M2 (unstimulated): 90/90 values ≥5 TPM, max 39.1126; DICE NK (unstimulated): 35/90 values ≥5 TPM, max 8.60777; DICE TREG_MEM (unstimulated): 64/89 values ≥5 TPM, max 8.61494; DICE CD4_NAIVE (unstimulated): 72/88 values ≥5 TPM, max 11.1159; DICE CD4_STIM (activated): 4/88 values ≥5 TPM, max 7.53764; DICE TREG_NAIVE (unstimulated): 83/89 values ≥5 TPM, max 12.1914; DICE TFH (unstimulated): 24/89 values ≥5 TPM, max 8.47375; DICE TH1 (unstimulated): 22/81 values ≥5 TPM, max 8.18315; DICE TH2 (unstimulated): 18/89 values ≥5 TPM, max 7.37337; DICE CD8_NAIVE (unstimulated): 86/89 values ≥5 TPM, max 14.0219; DICE CD8_STIM (activated): 20/88 values ≥5 TPM, max 9.34729; hpa_immune_cell classical monocyte: 12.5 nTPM; hpa_immune_cell intermediate monocyte: 15.8 nTPM; hpa_immune_cell myeloid DC: 17.7 nTPM; hpa_immune_cell non-classical monocyte: 31.2 nTPM; hpa_immune_cell total PBMC: 10.6 nTPM; hpa_immune_monaco basophil: 5 TPM; hpa_immune_monaco classical monocyte: 17.6 TPM; hpa_immune_monaco Exhausted memory B-cell: 5.9 TPM; hpa_immune_monaco intermediate monocyte: 30.6 TPM; hpa_immune_monaco myeloid DC: 20.3 TPM; hpa_immune_monaco naive B-cell: 5.6 TPM; hpa_immune_monaco neutrophil: 5.2 TPM; hpa_immune_monaco non-classical monocyte: 37.5 TPM; hpa_immune_monaco Non-switched memory B-cell: 5 TPM; hpa_immune_monaco plasmacytoid DC: 10.2 TPM; hpa_immune_monaco Progenitor cell: 28.5 TPM; hpa_immune_monaco Switched memory B-cell: 5.1 TPM; hpa_immune_monaco total PBMC: 10.8 TPM
Cell RNA findings: pbmc/platelets cluster c-9: 5316.5 nTPM, 559 reads; reproductive-cell max 1326.2
HPA v23 gene record · Previous decision and measured antibodies
HORMAD1
Neither → Neither / Cellular. Normal-cell RNA or uncertain antibody evidence requires review; not labelled proven clinical toxicity or added to forbidden proteins
Maximum outside explicitly permitted contexts: 14.8 nTPM and 19.733 TPM (separate units). Reproductive bulk maximum: 114.3 nTPM.
Open question: Why is RNA repeatedly detected in monocytes and naive B cells despite reproductive-positive curated IHC?
Evidence needed: Review gene-specific read mapping and obtain reliable protein evidence in the implicated immune populations.
Limits: DICE observations are not paired RNA/IHC donors; negative bulk-organ IHC does not assess every sorted immune population.
Immune RNA findings: DICE B_CELL_NAIVE (unstimulated): 33/91 values ≥5 TPM, max 11.3605; DICE MONOCYTES (unstimulated): 90/91 values ≥5 TPM, max 19.7327; DICE M2 (unstimulated): 48/90 values ≥5 TPM, max 14.6589; hpa_immune_monaco neutrophil: 5.7 TPM
HPA v23 gene record · Previous decision and measured antibodies
TDRD1
Neither → Neither / Cellular. Normal-cell RNA or uncertain antibody evidence requires review; not labelled proven clinical toxicity or added to forbidden proteins
Maximum outside explicitly permitted contexts: 10.8 nTPM and 6.434 TPM (separate units). Reproductive bulk maximum: 15.2 nTPM.
Open question: Are the few activated-CD4 values and Monaco plasmacytoid-DC summary reproducible?
Evidence needed: Resolve the borderline immune RNA with source-specific read review and reliable local protein evidence.
Limits: Three of 88 activated-CD4 DICE values reach 5 TPM; this is a review threshold rather than demonstrated toxicity.
Immune RNA findings: DICE CD4_STIM (activated): 3/88 values ≥5 TPM, max 6.43364; hpa_immune_monaco plasmacytoid DC: 6.4 TPM
HPA v23 gene record · Previous decision and measured antibodies
BRDT
Neither → Neither / Cellular. Normal-cell RNA or uncertain antibody evidence requires review; not labelled proven clinical toxicity or added to forbidden proteins
Maximum outside explicitly permitted contexts: 17.7 nTPM and 6 TPM (separate units). Reproductive bulk maximum: 127.6 nTPM.
Open question: Does the Monaco-only borderline signal reflect genuine immune expression?
Evidence needed: Reconcile Monaco CD8/basophil RNA with the much lower DICE values and obtain relevant protein evidence.
Limits: Monaco summary values 5 and 6 TPM are weaker evidence than recurrent high original-sample RNA; DICE does not sample basophils.
Immune RNA findings: hpa_immune_monaco basophil: 5 TPM; hpa_immune_monaco Effector memory CD8 T-cell: 6 TPM
HPA v23 gene record · Previous decision and measured antibodies
TEX101
Neither → Unsafe / High RNA. Observed RNA above 30 TPM or nTPM outside explicitly permitted reproductive/disposable contexts; research exclusion, not proven clinical toxicity
Maximum outside explicitly permitted contexts: 119.722 nTPM and 74.9 TPM (separate units). Reproductive bulk maximum: 114.4 nTPM.
Open question: What explains high basophil RNA in HPA and Monaco?
Evidence needed: Resolve basophil RNA identity and local protein evidence before reconsideration.
Limits: TPM and nTPM are separate measurements; DICE has no basophil population.
High normal RNA findings: hpa_immune_cell: blood/basophil, max 55.7 nTPM, 1 observations >30; hpa_immune_cell_samples: blood/basophil, max 66.4757 TPM, 2 observations >30; hpa_immune_cell_samples: blood/basophil, max 119.722 nTPM, 2 observations >30; hpa_immune_monaco: blood/basophil, max 74.9 TPM, 1 observations >30
Immune RNA findings: hpa_immune_cell basophil: 55.7 nTPM; hpa_immune_monaco basophil: 74.9 TPM
HPA v23 gene record · Previous decision and measured antibodies
DAZL
Neither → Neither / Cellular. Normal-cell RNA or uncertain antibody evidence requires review; not labelled proven clinical toxicity or added to forbidden proteins
Maximum outside explicitly permitted contexts: 2.7 nTPM and 8.913 TPM (separate units). Reproductive bulk maximum: 77.3 nTPM.
Open question: Is the naive-B-cell RNA translated in normal B cells?
Evidence needed: Review gene-specific mapping and reliable protein evidence in naive B cells.
Limits: Reproductive-positive Enhanced IHC does not establish absence in the particular sorted immune cells measured by RNA.
Immune RNA findings: DICE B_CELL_NAIVE (unstimulated): 16/91 values ≥5 TPM, max 8.91336; hpa_immune_monaco naive B-cell: 7.5 TPM
HPA v23 gene record · Previous decision and measured antibodies
FOXR2
Neither → Neither / Antibody. Normal-cell RNA or uncertain antibody evidence requires review; not labelled proven clinical toxicity or added to forbidden proteins
Maximum outside explicitly permitted contexts: 0 nTPM and 0.513 TPM (separate units). Reproductive bulk maximum: 1.2 nTPM.
Open question: Which primary antibody staining is specific to FOXR2?
Evidence needed: Resolve discordance between HPA034487 and HPA057358 using independently validated protein evidence.
Limits: Both profiles are Uncertain; reproductive/tumor publication support does not validate normal-organ staining or waive counterevidence.
Antibody findings: Cerebral cortex/Endothelial cells: Low, HPA034487; conflicting or uncurated primary profile; Colon/Peripheral nerve/ganglion: Low, HPA034487; conflicting or uncurated primary profile; Lymph node/Non-germinal center cells: Low, HPA034487; conflicting or uncurated primary profile; Pancreas/Exocrine glandular cells: Medium, HPA034487; conflicting or uncurated primary profile; Skeletal muscle/Myocytes: Medium, HPA034487; conflicting or uncurated primary profile; Skin 1/Keratinocytes: Low, HPA034487; conflicting or uncurated primary profile; Skin 2/Epidermal cells: Low, HPA034487; conflicting or uncurated primary profile; Thyroid gland/Glandular cells: Low, HPA034487; conflicting or uncurated primary profile; Adipose tissue/Adipocytes: Medium, HPA057358; conflicting or uncurated primary profile; Adrenal gland/Glandular cells: Medium, HPA057358; conflicting or uncurated primary profile; Bone marrow/Hematopoietic cells: Low, HPA057358; conflicting or uncurated primary profile; Bronchus/Respiratory epithelial cells: Low, HPA057358; conflicting or uncurated primary profile; Caudate/Glial cells: Medium, HPA057358; conflicting or uncurated primary profile; Cerebellum/Purkinje cells: Medium, HPA057358; conflicting or uncurated primary profile; Cerebral cortex/Endothelial cells: Low, HPA057358; conflicting or uncurated primary profile; Cerebral cortex/Neuronal cells: Medium, HPA057358; conflicting or uncurated primary profile; Cerebral cortex/Neuropil: Low, HPA057358; conflicting or uncurated primary profile; Colon/Endothelial cells: Medium, HPA057358; conflicting or uncurated primary profile; Heart muscle/Cardiomyocytes: Medium, HPA057358; conflicting or uncurated primary profile; Lung/Alveolar cells: Low, HPA057358; conflicting or uncurated primary profile; Lung/Macrophages: High, HPA057358; conflicting or uncurated primary profile; Nasopharynx/Respiratory epithelial cells: Low, HPA057358; conflicting or uncurated primary profile; Skin 1/Fibroblasts: Medium, HPA057358; conflicting or uncurated primary profile; Skin 2/Epidermal cells: Low, HPA057358; conflicting or uncurated primary profile; Stomach 2/Glandular cells: Low, HPA057358; conflicting or uncurated primary profile; Thyroid gland/Glandular cells: Medium, HPA057358; conflicting or uncurated primary profile
Publication sources: https://pmc.ncbi.nlm.nih.gov/articles/PMC9437574/
HPA v23 gene record · Previous decision and measured antibodies
CTAG2
Neither → Neither / Variable. Donor-variable vital RNA with negative local IHC; excluded from targets and forbidden background pending review
Maximum outside explicitly permitted contexts: 24.9 nTPM and 5.075 TPM (separate units). Reproductive bulk maximum: 10.1 nTPM.
Open question: When and why do some normal heart specimens contain CTAG2 RNA?
Evidence needed: Resolve donor variability and obtain paired RNA/protein information from the implicated cardiac context.
Limits: RNA donors and negative-IHC donors differ; neither absence of established target-mediated toxicity nor separate negative specimens clears the positive RNA donors.
Donor findings: 149: 13.5 nTPM (fails); 150: 0 nTPM (passes); 151: 0 nTPM (passes); 152: 7.1 nTPM (fails)
HPA v23 gene record · Previous decision and measured antibodies
GAGE12F
Neither → Unsafe / High RNA. Observed RNA above 30 TPM or nTPM outside explicitly permitted reproductive/disposable contexts; research exclusion, not proven clinical toxicity
Maximum outside explicitly permitted contexts: 83.07 nTPM and 71.665 TPM (separate units). Reproductive bulk maximum: 103.3 nTPM.
Open question: Is the immune signal correctly assigned within the GAGE family?
Evidence needed: Review uniquely assigning reads and exact gene/protein identity before reconsidering local expression.
Limits: Highly related paralogs can complicate attribution; no paralog substitution or RNA-to-protein inference is permitted.
High normal RNA findings: hpa_immune_cell_samples: blood/NK-cell, max 51.8037 TPM, 1 observations >30; hpa_immune_cell_samples: blood/T-reg, max 71.6653 TPM, 1 observations >30; hpa_immune_cell_samples: blood/classical monocyte, max 38.8727 TPM, 1 observations >30; hpa_immune_cell_samples: blood/intermediate monocyte, max 32.0759 TPM, 1 observations >30; hpa_immune_cell_samples: blood/memory CD4 T-cell, max 46.1675 TPM, 1 observations >30; hpa_immune_cell_samples: blood/naive CD4 T-cell, max 35.4421 TPM, 1 observations >30; hpa_immune_cell_samples: blood/naive CD8 T-cell, max 33.0234 TPM, 1 observations >30; hpa_immune_cell_samples: blood/plasmacytoid DC, max 41.922 TPM, 1 observations >30; hpa_immune_cell_samples: blood/total PBMC, max 40.9921 TPM, 1 observations >30; hpa_immune_cell_samples: blood/NK-cell, max 53.5002 nTPM, 1 observations >30; hpa_immune_cell_samples: blood/T-reg, max 83.0695 nTPM, 1 observations >30; hpa_immune_cell_samples: blood/classical monocyte, max 46.6655 nTPM, 1 observations >30; hpa_immune_cell_samples: blood/intermediate monocyte, max 47.1668 nTPM, 1 observations >30; hpa_immune_cell_samples: blood/memory B-cell, max 33.8287 nTPM, 1 observations >30; hpa_immune_cell_samples: blood/memory CD4 T-cell, max 49.0849 nTPM, 1 observations >30; hpa_immune_cell_samples: blood/naive B-cell, max 32.1517 nTPM, 1 observations >30; hpa_immune_cell_samples: blood/naive CD4 T-cell, max 37.4272 nTPM, 1 observations >30; hpa_immune_cell_samples: blood/naive CD8 T-cell, max 32.3725 nTPM, 1 observations >30; hpa_immune_cell_samples: blood/non-classical monocyte, max 31.2073 nTPM, 1 observations >30; hpa_immune_cell_samples: blood/plasmacytoid DC, max 50.2688 nTPM, 1 observations >30; hpa_immune_cell_samples: blood/total PBMC, max 46.4602 nTPM, 1 observations >30
Immune RNA findings: hpa_immune_cell classical monocyte: 7.7 nTPM; hpa_immune_cell intermediate monocyte: 7.8 nTPM; hpa_immune_cell memory B-cell: 5.6 nTPM; hpa_immune_cell memory CD4 T-cell: 8.1 nTPM; hpa_immune_cell memory CD8 T-cell: 5.5 nTPM; hpa_immune_cell naive B-cell: 5.3 nTPM; hpa_immune_cell naive CD4 T-cell: 6.2 nTPM; hpa_immune_cell naive CD8 T-cell: 5.3 nTPM; hpa_immune_cell NK-cell: 8.9 nTPM; hpa_immune_cell non-classical monocyte: 6.2 nTPM; hpa_immune_cell plasmacytoid DC: 8.3 nTPM; hpa_immune_cell T-reg: 13.8 nTPM; hpa_immune_cell total PBMC: 7.7 nTPM
HPA v23 gene record · Previous decision and measured antibodies
PAGE2B
Neither → Unsafe / High RNA. Observed RNA above 30 TPM or nTPM outside explicitly permitted reproductive/disposable contexts; research exclusion, not proven clinical toxicity
Maximum outside explicitly permitted contexts: 35 nTPM and 8.043 TPM (separate units). Reproductive bulk maximum: 55.0 nTPM.
Open question: Are borderline DICE B-cell RNA and other cell-context signals genuine?
Evidence needed: Review exact loci and source-specific normal-cell signals; reliable protein evidence must address implicated cells.
Limits: A borderline immune summary must not hide a higher signal elsewhere; complete RNA audit accompanies this record.
High normal RNA findings: hpa_single_cell_tissue: liver/erythroid cells, max 35 nTPM, 1 observations >30
Immune RNA findings: DICE B_CELL_NAIVE (unstimulated): 3/91 values ≥5 TPM, max 8.04323
HPA v23 gene record · Previous decision and measured antibodies
TRIP13
Neither → Unsafe / High RNA. Observed RNA above 30 TPM or nTPM outside explicitly permitted reproductive/disposable contexts; research exclusion, not proven clinical toxicity
Maximum outside explicitly permitted contexts: 88.8 nTPM and 8.639 TPM (separate units). Reproductive bulk maximum: 29.0 nTPM.
Open question: Does its broader normal-cell expression permit a reproductive-restricted classification?
Evidence needed: Resolve the documented non-permitted cell expression before any reproductive-restricted designation.
Limits: Tumor relevance and reproductive enrichment do not establish normal-cell restriction.
High normal RNA findings: hpa_single_cell: /Ciliated cells, max 46.8 nTPM, 1 observations >30; hpa_single_cell_tissue: adipose tissue/t-cells, max 33.6 nTPM, 1 observations >30; hpa_single_cell_tissue: bone marrow/plasma cells, max 37.8 nTPM, 1 observations >30; hpa_single_cell_tissue: bronchus/ciliated cells, max 51.6 nTPM, 1 observations >30; hpa_single_cell_tissue: liver/erythroid cells, max 35 nTPM, 1 observations >30; hpa_single_cell_tissue: lung/ciliated cells, max 88.8 nTPM, 1 observations >30; hpa_single_cell_tissue: pancreas/fibroblasts, max 30.1 nTPM, 1 observations >30; hpa_single_cell_tissue: placenta/mixed immune cells, max 60.2 nTPM, 1 observations >30; hpa_single_cell_tissue: spleen/plasma cells, max 45.7 nTPM, 1 observations >30; hpa_single_cell_tissue: thymus/plasma cells, max 48.4 nTPM, 2 observations >30
Immune RNA findings: DICE CD4_STIM (activated): 8/88 values ≥5 TPM, max 7.21408; DICE CD8_STIM (activated): 41/88 values ≥5 TPM, max 8.63936; hpa_immune_monaco Plasmablast: 7.4 TPM
HPA v23 gene record · Previous decision and measured antibodies
CTAGE1
Neither → Neither / Antibody. Normal-cell RNA or uncertain antibody evidence requires review; not labelled proven clinical toxicity or added to forbidden proteins
Maximum outside explicitly permitted contexts: 1.9 nTPM and 0.388 TPM (separate units). Reproductive bulk maximum: 10.0 nTPM.
Open question: Can the uncertain primary-antibody normal staining be resolved?
Evidence needed: Use independently validated protein evidence to adjudicate primary staining conflicts.
Limits: An uncertain antibody is not reliable proof of either expression or absence.
Antibody findings: Adrenal gland/Glandular cells: High, HPA000387; conflicting or uncurated primary profile; Bone marrow/Hematopoietic cells: Medium, HPA000387; conflicting or uncurated primary profile; Caudate/Glial cells: Low, HPA000387; conflicting or uncurated primary profile; Caudate/Neuronal cells: High, HPA000387; conflicting or uncurated primary profile; Cerebellum/Cells in granular layer: Medium, HPA000387; conflicting or uncurated primary profile; Cerebellum/Cells in molecular layer: Medium, HPA000387; conflicting or uncurated primary profile; Cerebellum/Purkinje cells: Medium, HPA000387; conflicting or uncurated primary profile; Cerebral cortex/Endothelial cells: Low, HPA000387; conflicting or uncurated primary profile; Cerebral cortex/Glial cells: Low, HPA000387; conflicting or uncurated primary profile; Cerebral cortex/Neuronal cells: High, HPA000387; conflicting or uncurated primary profile; Colon/Endothelial cells: Low, HPA000387; conflicting or uncurated primary profile; Colon/Glandular cells: Medium, HPA000387; conflicting or uncurated primary profile; Duodenum/Glandular cells: High, HPA000387; conflicting or uncurated primary profile; Esophagus/Squamous epithelial cells: Low, HPA000387; conflicting or uncurated primary profile; Hippocampus/Glial cells: Low, HPA000387; conflicting or uncurated primary profile; Hippocampus/Neuronal cells: High, HPA000387; conflicting or uncurated primary profile; Kidney/Cells in tubules: Medium, HPA000387; conflicting or uncurated primary profile; Liver/Cholangiocytes: Low, HPA000387; conflicting or uncurated primary profile; Liver/Hepatocytes: Medium, HPA000387; conflicting or uncurated primary profile; Lung/Alveolar cells: Medium, HPA000387; conflicting or uncurated primary profile; Lung/Macrophages: High, HPA000387; conflicting or uncurated primary profile; Lymph node/Germinal center cells: Medium, HPA000387; conflicting or uncurated primary profile; Nasopharynx/Respiratory epithelial cells: High, HPA000387; conflicting or uncurated primary profile; Oral mucosa/Squamous epithelial cells: Medium, HPA000387; conflicting or uncurated primary profile; Pancreas/Exocrine glandular cells: High, HPA000387; conflicting or uncurated primary profile; Parathyroid gland/Glandular cells: Low, HPA000387; conflicting or uncurated primary profile; Rectum/Glandular cells: Low, HPA000387; conflicting or uncurated primary profile; Salivary gland/Glandular cells: High, HPA000387; conflicting or uncurated primary profile; Skin 1/Keratinocytes: Low, HPA000387; conflicting or uncurated primary profile; Skin 2/Epidermal cells: Medium, HPA000387; conflicting or uncurated primary profile; Small intestine/Glandular cells: High, HPA000387; conflicting or uncurated primary profile; Smooth muscle/Smooth muscle cells: Medium, HPA000387; conflicting or uncurated primary profile; Spleen/Cells in red pulp: Low, HPA000387; conflicting or uncurated primary profile; Spleen/Cells in white pulp: Low, HPA000387; conflicting or uncurated primary profile; Stomach 1/Glandular cells: High, HPA000387; conflicting or uncurated primary profile; Stomach 2/Glandular cells: High, HPA000387; conflicting or uncurated primary profile; Thyroid gland/Glandular cells: High, HPA000387; conflicting or uncurated primary profile; Urinary bladder/Urothelial cells: Medium, HPA000387; conflicting or uncurated primary profile; Adrenal gland/Glandular cells: Low, HPA000922; conflicting or uncurated primary profile; Bronchus/Respiratory epithelial cells: Medium, HPA000922; conflicting or uncurated primary profile; Caudate/Neuronal cells: Low, HPA000922; conflicting or uncurated primary profile; Cerebellum/Purkinje cells: Low, HPA000922; conflicting or uncurated primary profile; Cerebral cortex/Neuronal cells: Low, HPA000922; conflicting or uncurated primary profile; Colon/Glandular cells: Low, HPA000922; conflicting or uncurated primary profile; Duodenum/Glandular cells: Medium, HPA000922; conflicting or uncurated primary profile; Hippocampus/Neuronal cells: High, HPA000922; conflicting or uncurated primary profile; Kidney/Cells in tubules: Low, HPA000922; conflicting or uncurated primary profile; Liver/Hepatocytes: Low, HPA000922; conflicting or uncurated primary profile; Lung/Macrophages: Medium, HPA000922; conflicting or uncurated primary profile; Lymph node/Germinal center cells: Low, HPA000922; conflicting or uncurated primary profile; Nasopharynx/Respiratory epithelial cells: Medium, HPA000922; conflicting or uncurated primary profile; Pancreas/Exocrine glandular cells: Medium, HPA000922; conflicting or uncurated primary profile; Pancreas/Pancreatic endocrine cells: Medium, HPA000922; conflicting or uncurated primary profile; Rectum/Glandular cells: Low, HPA000922; conflicting or uncurated primary profile; Salivary gland/Glandular cells: Medium, HPA000922; conflicting or uncurated primary profile; Skin 2/Epidermal cells: Low, HPA000922; conflicting or uncurated primary profile; Small intestine/Glandular cells: Low, HPA000922; conflicting or uncurated primary profile; Stomach 1/Glandular cells: Medium, HPA000922; conflicting or uncurated primary profile; Stomach 2/Glandular cells: Medium, HPA000922; conflicting or uncurated primary profile; Thyroid gland/Glandular cells: Low, HPA000922; conflicting or uncurated primary profile; Urinary bladder/Urothelial cells: Low, HPA000922; conflicting or uncurated primary profile; Adrenal gland/Glandular cells: Low, CAB016204; conflicting or uncurated primary profile; Bone marrow/Hematopoietic cells: High, CAB016204; conflicting or uncurated primary profile; Bronchus/Respiratory epithelial cells: High, CAB016204; conflicting or uncurated primary profile; Cerebellum/Cells in molecular layer: Low, CAB016204; conflicting or uncurated primary profile; Colon/Glandular cells: Low, CAB016204; conflicting or uncurated primary profile; Esophagus/Squamous epithelial cells: High, CAB016204; conflicting or uncurated primary profile; Hippocampus/Glial cells: Low, CAB016204; conflicting or uncurated primary profile; Kidney/Cells in tubules: High, CAB016204; conflicting or uncurated primary profile; Liver/Cholangiocytes: Medium, CAB016204; conflicting or uncurated primary profile; Liver/Hepatocytes: High, CAB016204; conflicting or uncurated primary profile; Lung/Alveolar cells: Medium, CAB016204; conflicting or uncurated primary profile; Lung/Macrophages: Low, CAB016204; conflicting or uncurated primary profile; Lymph node/Non-germinal center cells: Medium, CAB016204; conflicting or uncurated primary profile; Nasopharynx/Respiratory epithelial cells: High, CAB016204; conflicting or uncurated primary profile; Oral mucosa/Squamous epithelial cells: High, CAB016204; conflicting or uncurated primary profile; Pancreas/Exocrine glandular cells: Medium, CAB016204; conflicting or uncurated primary profile; Rectum/Glandular cells: Medium, CAB016204; conflicting or uncurated primary profile; Salivary gland/Glandular cells: High, CAB016204; conflicting or uncurated primary profile; Skin 1/Langerhans: High, CAB016204; conflicting or uncurated primary profile; Spleen/Cells in red pulp: High, CAB016204; conflicting or uncurated primary profile; Stomach 1/Glandular cells: Low, CAB016204; conflicting or uncurated primary profile; Stomach 2/Glandular cells: Medium, CAB016204; conflicting or uncurated primary profile; Urinary bladder/Urothelial cells: High, CAB016204; conflicting or uncurated primary profile
HPA v23 gene record · Previous decision and measured antibodies
ZNF730
Neither → Neither / Cellular. Normal-cell RNA or uncertain antibody evidence requires review; not labelled proven clinical toxicity or added to forbidden proteins
Maximum outside explicitly permitted contexts: 11.3 nTPM and 7 TPM (separate units). Reproductive bulk maximum: 4.9 nTPM.
Open question: Does the full normal-cell distribution support reproductive restriction?
Evidence needed: Review diffuse RNA and missing reliable protein evidence rather than selecting the largest reproductive value.
Limits: A high reproductive maximum does not erase normal-cell expression; no clinical safety conclusion is recorded.
Immune RNA findings: hpa_immune_monaco Progenitor cell: 7 TPM
HPA v23 gene record · Previous decision and measured antibodies
MAGEA3
CTA → Unsafe / High RNA. Observed RNA above 30 TPM or nTPM outside explicitly permitted reproductive/disposable contexts; research exclusion, not proven clinical toxicity
Maximum outside explicitly permitted contexts: 53.1 nTPM and 0.166 TPM (separate units). Reproductive bulk maximum: 7.8 nTPM.
Open question: Is the colonic undifferentiated-cell RNA correctly attributed and endogenous?
Evidence needed: Resolve the pinned high normal-cell signal and exact locus/protein identity before reconsideration.
Limits: Clinical interest does not create a gene exception; RNA does not by itself establish protein or peptide display.
High normal RNA findings: hpa_single_cell_tissue: colon/undifferentiated cells, max 53.1 nTPM, 1 observations >30
HPA v23 gene record · Previous decision and measured antibodies
ROPN1
CTA → Unsafe / High RNA. Observed RNA above 30 TPM or nTPM outside explicitly permitted reproductive/disposable contexts; research exclusion, not proven clinical toxicity
Maximum outside explicitly permitted contexts: 32.9 nTPM and 0.595 TPM (separate units). Reproductive bulk maximum: 154.4 nTPM.
Open question: Is the salivary serous-cell RNA above 30 nTPM a genuine local signal?
Evidence needed: Review the underlying cluster and gene-specific reads with reliable local protein evidence before reconsideration.
Limits: The value is close to the hard ceiling; a general rule is applied rather than a benchmark exception.
High normal RNA findings: hpa_single_cell_tissue: salivary gland/serous glandular cells, max 32.9 nTPM, 1 observations >30
HPA v23 gene record · Previous decision and measured antibodies