Dog CTA evidence funnel

14 native nominations, all unassigned/unassessed. There is no completed canine quantitative selection or genome-wide denominator. None is automatically called Other. Human RNA ceilings, HPA grades and clinical evidence do not transfer by orthology.

citation mapped_entities mapped_gene_loci source_url
Hindriks et al. (2025) 10 9 Source
Nemec et al. (2019) 5 5 Source

Nemec et al. contributes 5 nominations; Hindriks et al. contributes 10; NT5C1B is shared, giving 14. Thirteen have unique gene mappings; one MAGE family assay remains ambiguous. A unique gene mapping does not establish identical protein isoforms.

Dog funnel

stage status note
Curated native nominations available 14 native nominations; not a genome-wide screen
Reference and assay identity partial 13 unique canine mappings and one ambiguous MAGE-family assay
Normal and reproductive/developmental RNA not_evaluated Bgee TPM and BarkBase TMM-CPM require native reference reconciliation
Tumor RNA not_evaluated GSE304066 count/FPKM and source-reference conflicts unresolved
Normal protein not_evaluated Study IHC is limited; Pfizer pooled iBAQ is not cell-resolved IHC
Quantitative selection not_evaluated No native species selection policy; no biological category assignment

Sources and gaps

name evidence_category native_unit status source_url
bgee-srp009687 normal_bulk_rna TPM native_matrix Source
bgee-srp009687 reproductive_expression TPM native_matrix Source
bgee-srp181218 normal_bulk_rna TPM native_matrix Source
bgee-srp181218 reproductive_expression TPM native_matrix Source
barkbase normal_bulk_rna TMM-CPM native_matrix Source
barkbase reproductive_expression TMM-CPM native_matrix Source
barkbase developmental_expression TMM-CPM native_matrix Source
pfizer-dog-protein normal_protein iBAQ native_matrix Source
doga normal_bulk_rna unresolved metadata_only Source
doga reproductive_expression unresolved metadata_only Source
doga developmental_expression unresolved metadata_only Source
pfizer-dog-rna normal_bulk_rna unresolved metadata_only Source
gse304066-osteosarcoma tumor_expression unresolved blocked_provenance Source
hindriks2025 nomination source-native observations; no absolute expression unit native_observations Source
hindriks2025 normal_bulk_rna source-native observations; no absolute expression unit native_observations Source
hindriks2025 normal_protein source-native observations; no absolute expression unit native_observations Source
hindriks2025 reproductive_expression source-native observations; no absolute expression unit native_observations Source
hindriks2025 tumor_expression source-native observations; no absolute expression unit native_observations Source
nemec2019 nomination source-native observations; no absolute expression unit native_observations Source
nemec2019 normal_bulk_rna source-native observations; no absolute expression unit native_observations Source
nemec2019 tumor_expression source-native observations; no absolute expression unit native_observations Source

Bgee and BarkBase include 46 overlapping libraries, not independent replication. BarkBase has 37,149 features × 150 TMM-CPM columns; Pfizer MS has 9,929 reported groups × 38 tissue pools and missing matrix cells. Pooled iBAQ is not cell-specific IHC or antigen presentation. Tumor GSE304066 count/FPKM and reference provenance remain unresolved. These quantities must retain their native scales.

RNA/reference/lineage integration issue #574 and Pfizer MS integration issue #585 track the main work. Systematic canine IHC and normal-cell atlases remain coverage gaps. Pairwise nomination overlaps.

The same API exposes sources, memberships, overlaps, criteria, funnel and explanations for human, dog and mouse; unavailable evaluations have null counts and null biological categories.