Personalized Immunotherapy Research Lab

The Personalized Immunotherapy Research Lab (PIRL) is a multi-investigator research group at the University of North Carolina’s School of Medicine, whose members bring together expertise in immunology, genomics, oncology, and machine learning. We work on developing cancer immunotherapies that use a patient’s immune system to attack tumor-specific targets. We are committed to open science through building open source research software, making experimental data unconditionally available, and disseminating results quickly through blog posts and preprints.

Blog Posts

  1. OpenAI Foundation gave us $40M to improve cancer vaccines

    We're starting the Initiative for Generative Immunotherapy at UNC to release unusually rich data from tumors and the T cells that recognize them

  2. Announcing RAFT v1.5.1 and LENS v1.9.0

    We’re excited to announce the latest RAFT and LENS releases.

  3. Some advice to companies and clinics starting personalized neoantigen vaccine programs

    The problems aren't all solved yet...

  4. Quantifying Tumor Antigen Heterogeneity with TAHP

    Tumor antigens play a crucial role in guiding therapeutic development.

  5. Expanding the Unified Grammar for RNA Variants

    A unified toolkit for identifying and integrating DNA and RNA variants. Part 2 of the Neoantigen Discovery with Long-read Sequencing series.

  6. Inversion: Temporal Pincer in Cancer Genome

    Head-to-head (5' to 5') and tail-to-tail (3' to 3') inversion breakpoints explained.