{
  "reference": "PMID:26871591",
  "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4752330/",
  "source_locator": "Table 2 and Whole Exome Sequencing methods",
  "source_xml_url": "https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4752330/fullTextXML",
  "source_xml_sha256": "11aa4f6a8e1407afd6a8047411f6ad05ea964bfd2e478b066348046357a85de8",
  "nominal_capture_mb": [
    44.1,
    50.0
  ],
  "selected_rounded_estimate_mut_mb": 0.2,
  "statistic": "approximate",
  "method": "Median of unflagged nonsynonymous counts divided by each nominal capture size, rounded to one decimal; no sample-specific kit or callable-base denominator inferred.",
  "limitations": "Approximate 0.2 mut/Mb from five classic HCL exomes: unflagged nonsynonymous counts 10,22,7,10,4 have median 10; divide by nominal 44.1-50 Mb capture sizes to obtain 0.20-0.23. Not a published TMB median or an independently validated callable-coding rate; sample-specific platform assignments and callable intersections are unavailable. Restrictive variant filtering matters: all candidate nonsynonymous counts 19,32,14,34,19 yield 0.38-0.43 by the same approximation. Ranges describe method sensitivity, not confidence intervals. Same rounded point as the withdrawn 0.2, with a different source and explicit approximate provenance.",
  "sensitivity": [
    {
      "count_definition": "unflagged_nonsynonymous",
      "n": 5,
      "median_count": 10,
      "mean_count": 10.6,
      "median_count_per_nominal_mb": [
        0.22675736961451246,
        0.2
      ]
    },
    {
      "count_definition": "total_candidate_nonsynonymous",
      "n": 5,
      "median_count": 19,
      "mean_count": 23.6,
      "median_count_per_nominal_mb": [
        0.43083900226757366,
        0.38
      ]
    }
  ]
}