{
  "male_reproductive_maternal_fetal_excluded": {
    "policy_id": "oncoref.normal-tissue-gene-filters.2026-10-20.1",
    "label": "Postnatal male reproductive only; maternal and developmental exclusion",
    "intent": "Pregnancy-oriented candidate restriction, not pregnancy safety",
    "allowed": "Postnatal male reproductive anatomy in male samples only",
    "excluded": "Every other normal context, including fetal male reproductive tissues",
    "required_negative_domains": [
      "female_somatic",
      "female_reproductive",
      "pregnant_maternal",
      "embryonic",
      "fetal",
      "fetal_male_gonad",
      "fetal_female_gonad",
      "placental",
      "other_extraembryonic"
    ]
  },
  "female_developmental_male_reproductive_excluded": {
    "policy_id": "oncoref.normal-tissue-gene-filters.2026-10-20.1",
    "label": "Female/developmental only; male reproductive exclusion",
    "intent": "Male reproductive preservation candidate restriction, not proven fertility preservation",
    "allowed": "Female reproductive samples plus embryonic, fetal and extraembryonic contexts",
    "excluded": "Male reproductive anatomy at every stage; other postnatal contexts",
    "required_negative_domains": [
      "male_reproductive",
      "male_somatic",
      "male_mammary"
    ]
  }
}