{
  "policy_id": "oncoref.cta-screen.2026-10-23.1",
  "basis": "HPA v23 human research screen",
  "negative_ihc_relaxation": "requires reliable reproductive positive in curated gene profile",
  "positive_control_scope": "curated gene profile; antibody/run/specimen matching not established",
  "selectivity_increment": 0.05,
  "allowance_ntpm": 0.1,
  "absolute_ceilings": {
    "Vital": [
      2,
      4,
      6,
      12
    ],
    "Protected": [
      6,
      8,
      12,
      24
    ],
    "Manageable": [
      10,
      20,
      30,
      60
    ]
  },
  "selectivity_minima": {
    "Vital": [
      0.8,
      0.75,
      0.7,
      0.65
    ],
    "Protected": [
      0.75,
      0.7,
      0.65,
      0.6
    ],
    "Manageable": [
      0.7,
      0.65,
      0.6,
      0.55
    ]
  },
  "confidence_order": [
    "Missing/uncertain or no reproductive control",
    "Approved",
    "Supported",
    "Enhanced"
  ],
  "donor_rule": "apply the same absolute, selectivity and R>N rules to each reviewed vital donor",
  "variable": "reported zero and failing donor in same cohort/tissue; complete local negative IHC; no competing hard exclusion/quality flag",
  "variable_selected": false,
  "unreviewed_donors": "Not assessed",
  "donor_model_fitted": false,
  "clinical_safety_probability": null
}