{
  "policy": "oncoref.linked-normal-rna.2026-10-27.1",
  "scenarios": [
    {
      "scenario": "linked_recurrence_selected",
      "genes": 244,
      "controls": 8,
      "Neither": 142,
      "CTA": 96,
      "Unsafe": 6
    },
    {
      "scenario": "linked_maximum_tumor_selected",
      "genes": 337,
      "controls": 8,
      "Neither": 187,
      "CTA": 141,
      "Unsafe": 9
    },
    {
      "scenario": "linked_tumor30_selected",
      "genes": 197,
      "controls": 8,
      "Neither": 108,
      "CTA": 82,
      "Unsafe": 7
    },
    {
      "scenario": "linked_recurrence_legacy_cornea_selected",
      "genes": 248,
      "controls": 8,
      "Neither": 144,
      "CTA": 98,
      "Unsafe": 6
    },
    {
      "scenario": "linked_maximum_tumor_legacy_cornea_selected",
      "genes": 341,
      "controls": 8,
      "Neither": 189,
      "CTA": 143,
      "Unsafe": 9
    },
    {
      "scenario": "linked_tumor30_legacy_cornea_selected",
      "genes": 201,
      "controls": 8,
      "Neither": 110,
      "CTA": 84,
      "Unsafe": 7
    }
  ],
  "ihc_evaluated_genes": 2960,
  "maximum_tumor_lost": 6,
  "maximum_tumor_gained": 99,
  "exact_cell_ihc_matches": 3618,
  "cell_ihc_relaxations": 2960,
  "assessed_cell_contexts": 793280,
  "ihc_factors": {
    "Missing/uncertain": 1,
    "Approved": 1,
    "Supported": 1,
    "Enhanced": 1
  },
  "maximum_tumor_floor_ptpm": 10.0,
  "scope": "Shared normal-RNA ladder applied to every gene passing association, protein and coverage gates under either tumor rule; old uniform RNA caps do not restrict the pool.",
  "tumor_source": "HPA 25.1 native pTPM; 21 TCGA and 10 validation cohorts; other OncoRef cohorts not queried.",
  "bulk_rule": "Uncapped existing tissue/IHC absolute ladder; inclusive ceilings; no legacy selectivity gate.",
  "cell_rule": "Same tissue/IHC ladder and inclusive boundary as bulk; identified immune cells default to Protected, with no Manageable subset exceptions.",
  "protein_rule": "Original detected-normal-IHC exclusion retained, including uncertain staining; uncertain signal is a hold, not verified protein.",
  "age_scope": "Normal panels used by the adult research screen; no pediatric normal panel or age-stratified validation.",
  "context_rule": "Immune cells sampled in an explicit reproductive or developmental context are neutral for normal exclusion; blood and other tissues remain screened. Neutral observations cannot provide positive reproductive admission.",
  "historical_uniform_genes": 447,
  "context_neutral_uniform_gained": 10,
  "screened_cluster_panel": [
    399
  ],
  "neutral_cluster_panel": [
    27
  ],
  "cornea_rule": "Native CP10K ceiling is the shared per-million ceiling divided by 100. This is nominal policy linkage, not calibrated equivalence to TPM. Original 1 CP10K is reported only as a sensitivity.",
  "reference_rule": "Review begins at 2x the shared candidate ceiling. This provisional multiplier is not a validated toxicity boundary or an automatic sequence-reference change.",
  "assay_deviations": [],
  "historical_uniform_maximum_tumor_lost": 9,
  "historical_uniform_maximum_tumor_gained": 112
}